Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

A curve model for association of serum homocysteine with carotid artery hemodynamics

Zewei Wu¹, Yufeng Wen¹ , Mengxue Liu¹, Haibo Li¹, Yu Zhu¹, Huiping Zhang², Tiantian Ren²

¹School of Public Health, Wannan Medical College, Wuhu City, Anhui Province 241002; ²Department of Medical Ultrasonics, Ma'anshan People's Hospital, Maâ€™anshan City, Anhui Province 243000, PR China.

For correspondence:- Yufeng Wen Email: wyf@wnmc.edu.cn Tel:+865533932059

Received: 22 February 2017 Accepted: 19 July 2017 Published: 31 August 2017

Citation: Wu Z, Wen Y, Liu M, Li H, Zhu Y, Zhang H, et al. A curve model for association of serum homocysteine with carotid artery hemodynamics. Trop J Pharm Res 2017; 16(8):1983-1988 doi: 10.4314/tjpr.v16i8.31

© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the correlation between carotid artery hemodynamics and serum homocysteine.

Methods: A total of 894 participants made up of 439 male (49.11 %) and 455 female (50.89 %) from Ma’anshan, China, enrolled in the cross-sectional study. Data collection included demographics, blood sample and carotid ultrasonography. Piecewise linear regression analysis was used to analyze the relationship between serum homocysteine and carotid artery hemodynamics.

Results: Homocysteine (Hcy) levels were divided into four groups by quartiles. The populations of the groups were 226, 220, 222, 226; and their mean ages were 56.52 ± 10.49, 62.27 ± 10.06, 63.42 ± 9.81 and 65.38 ± 10.56 years, respectively. After adjustment for blood biochemical and demographics factors, U-shaped and S-shaped curves were as observed between Hcy and carotid artery hemodynamics. The adjusted regression analysis showed that the threshold values of Hcy with end diastolic velocity (EDV) of right common carotid artery (CCA) were 12.50 and 19.00, while for the EDV of right internal carotid artery (ICA), the values were 11.50 and 22.00. U-shaped curves were observed between Hcy and peak systolic velocity (PSV) of left CCA, EDV of left CCA, PSV of left ICA and EDV of left ICA. The threshold values of Hcy with PSV of left CCA, EDV of left CCA, PSV of left ICA and EDV of left ICA were 14.00, 14.00, 14.00 and 13.50, respectively.

Conclusion: These results indicate that a significant correlation exists between homocysteine at different concentrations and carotid artery hemodynamics.

Keywords: Homocysteine, Hemodynamics, End diastolic velocity, Peak systolic velocity