Anthony O Onyekweli1 
,
Cyril O Usifoh2,
Lucky O Okunrobo2,
Jessica D Zuofa1
For correspondence:- Anthony Onyekweli Email: okweli@yahoo.com
Published: 20 June 2003
Citation: Onyekweli AO, Usifoh CO, Okunrobo LO, Zuofa JD. Adsorptive property of kaolin in some drug formulations. Trop J Pharm Res 2003; 2(1):155-159 doi: 10.4314/tjpr.v2i1.5
© 2003 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: Kaolin is a known adsorbent, has lubricant property in powders and is therefore proposed as a lubricant in tablet formulations. This study was carried out to evaluate whether kaolin can adsorb some active drugs when mixed with them in tablet formulations even at very low concentrations.
Method: Chloroquine and chlorpheniramine tablets were formulated with powder mixtures containing various concentrations of kaolin. The effect of kaolin on the physical properties of the tablets were examined and compared with those of standard lubricants like magnesium stearate and talc. Chloroquine and chlorpheniramine tablets and powders of amoxicillin/clavulanic acid oral powder and ampicillin/cloxacillin injection were also mixed with and without various concentrations of kaolin in water. Chemical assay of the drugs in the solutions were determined over time.
Results: Kaolin significantly reduced the amount of each of the drugs in the solutions containing kaolin.
Conclusion: Kaolin reduces the amount of some drugs when incorporated in drug formulations. Therefore, its inclusion in such drug formulations should not be encouraged.
Archives
News Updates
Fulltext in PDF