Tropical Journal of Pharmaceutical Research

Review Article | OPEN ACCESS

Advances in pharmacology of isatin and its derivatives: A review

Farhan A Khan¹ , Aneela Maalik¹, Tayyaba Noor², Asma Zaidi¹, Umar Farooq¹, Syed Majid Bukhari¹

¹Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060, KPK, Pakistan; ²School of Chemical and Materials Engineering, National University of Science and Technology, Islamabad, Pakistan.

For correspondence:- Farhan Khan Email: farhankhan@ciit.net.pk Tel:+92334728 6986

Received: 9 January 2015 Accepted: 29 August 2015 Published: 31 October 2015

Citation: Khan FA, Maalik A, Noor T, Zaidi A, Farooq U, Bukhari SM. Advances in pharmacology of isatin and its derivatives: A review. Trop J Pharm Res 2015; 14(10):1937-1942 doi: 10.4314/tjpr.v14i10.28

© 2015 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Isatin (1H-indole-2,3-dione), an indole derivative of plant origin, is involved in many pharmacological activities like antiallergic, antimalarial, antiviral and antimicrobial; isatin and its derivatives have been found to show promising results against various cancer cell lines. Isatin is a versatile precursor for many biologically active molecules and its diversified nature makes it a versatile substrate for further modifications. This review provides a brief overview on the recent advances and future perspectives on pharmacological aspects of isatin and its derivatives reported in the last decade.

Keywords: Isatin, Anticancer, Antimicrobial, Monoamine oxidase, Antiviral