Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Anesthetic and hemodynamic effects of etomidate-remifentanil combination in laparoscopic surgery

Yu Yao¹ , Feng-juan Wang¹, Jie Liu², Zhen-zhong Wu³, Jin-zhuo Wang⁴, Jingming Zhao⁵

¹Department of Anesthesiology; ²Nursing Department, Affiliated Hospital to Changchun University of Chinese Medicine; ³Department of Anesthesiology, Jilin Province Qianwei Hospital; ⁴Department of Anesthesiology, Changchun Obstetrics-Gynecology Hospital; ⁵Department of Proctology, Affiliated Hospital to Changchun University of Chinese Medicine, Changchun City, China.

For correspondence:- Yu Yao Email: rn1164@163.com

Accepted: 24 December 2018 Published: 31 January 2019

Citation: Yao Y, Wang F, Liu J, Wu Z, Wang J, Zhao J. Anesthetic and hemodynamic effects of etomidate-remifentanil combination in laparoscopic surgery. Trop J Pharm Res 2019; 18(1):167-171 doi: 10.4314/tjpr.v18i1.25

© 2019 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To study the anesthetic and hemodynamic effects of etomidate-remifentanil combination treatment in laparoscopic surgery.

Methods: Patients scheduled for gynecological laparoscopic surgery (n = 120) were assigned to test and control groups (60 patients each). Etomidate combined with remifentanil anesthesia was used in the test group, while propofol-remifentanil combination anesthesia was used in the control group. The effect of anesthesia on awakening time, extubation time, pain relief time, systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) of patients before and after the extubation were observed and recorded for the two groups.

Results: Excellent rating was 98.0 % in the test group, and was superior to the corresponding rating of 86.0 % in the control group. Anesthesia time, awakening time, extubation time and pain relief time were markedly shorter in the test group than in controls (p < 0.05). However, there were no significant differences in SBP, DBP and HR of patients with tracheal intubation between the two groups (p > 0.05). The results were similar in patients with laparoscopic placement. After laparoscopic placement and tracheal extubation, significant decreases in SBP and HR in the test group were seen, relative to control patients (p < 0.05).

Conclusion: The anesthetic effect of etomidate combined with remifentanil is superior to that of propofol and remifentanil, and ensures stability of hemodynamic parameters such as SBP, DBP and HR during the period of anesthesia

Keywords: Etomidate, Remifentanil, Propofol, Laparoscopic surgery, Hemodynamic parameters