Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Anesthetic effect of sufentanil in patients undergoing cardiovascular surgery

Cheng Yuan¹, Dan Wang², Qing Cheng¹

¹Emergency Department, Taikang Tongji (Wuhan) Hospital, Wuhan City, 430000 Hubei Province, China; ²Dermatological Department, Taikang Tongji (Wuhan) Hospital, Wuhan City, 430000 Hubei Province, China.

For correspondence:- Qing Cheng Email: chengqing28@yeah.net Tel:+8613667100686

Accepted: 28 March 2023 Published: 29 April 2023

Citation: Yuan C, Wang D, Cheng Q. Anesthetic effect of sufentanil in patients undergoing cardiovascular surgery. Trop J Pharm Res 2023; 22(4):927-932 doi: 10.4314/tjpr.v22i4.28

© 2023 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the effect of sufentanil on anesthesia in patients undergoing cardiovascular surgery.

Methods: The subjects comprised a total of 100 patients who were scheduled to undergo cardiovascular surgery in Taikang Tongji (Wuhan) Hospital from January 2021 to December 2021 and met the inclusion criteria. The eligible patients were assigned in a ratio of 1:1 to receive either remifentanil (control group) or sufentanil (study group) during cardiovascular surgery, with 50 patients in each group. The anesthetic effect of remifentanil and sufentanil was compared.

Results: Patients treated with sufentanil experienced a faster onset of anesthesia and a shorter time-lapse before extubation, postoperative spontaneous breathing recovery, and postoperative anesthesia recovery when compared with those administered with remifentanil (p < 0.05). Sufentanil provided more potent pain mitigation for patients undergoing cardiovascular surgery than remifentanil, as shown by the lower visual analogue scale (VAS) scores of patients in the study group (p < 0.05). Patients administered with sufentanil showed better levels of mean arterial pressure (MAP) and oxygen saturation (SpO₂) than remifentanil, suggesting better hemodynamic benefits provided by sufentanil (p < 0.01). During cardiovascular surgery performed in this study, sufentanil resulted in a higher safety profile by reducing significantly the incidence of adverse reactions (6 %) than remifentanil (30 %) (p < 0.01).

Conclusions: Sufentanil exhibits a better anesthetic effect in patients undergoing cardiovascular surgery than remifentanil. It provides potent pain mitigation, effectively ameliorates patients’ hemodynamic status, and reduces the risk of adverse reactions. Future studies with larger sample sizes are required to validate these findings.

Keywords: Sufentanil, Cardiovascular surgery, Anesthesia, Effect analysis