Ming-xia Li1, Hong Liu2, Yan Li3, Fei Wang4, Pei-rong Zhang5, Ping Zang6
1College of Nursing, Shandong University of Traditional Chinese Medicine, Jinan, 250355; 2Department of Business Development, Affiliated Hospital of Weifang Medical University; 3ICU, Weifang Traditional Chinese Hospital; 4Department of Neurosurgery; 5ICU; 6Public Health Management Office, Affiliated Hospital of Weifang Medical University, Weifang, 261031, Shandong, China.For correspondence:- Ping Zang Email:
Received: 29 September 2014 Revised: 17 January 2015 Published: 28 February 2015
Citation: Li M, Liu H, Li Y, Wang F, Zhang P, Zang P. Anti-hyperprolactinemic effect of formula malt decoction, a Chinese herbal cocktail. Trop J Pharm Res 2015; 14(2):263-269 doi: 10.4314/tjpr.v14i2.11
© 2015 The authors.
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Purpose: To investigate the anti-hyperprolactinemic activity of Formula Malt Decoction (FMD), a Chinese herbal mixture.
Methods: The effect of FMD on serum prolactin (PRL), estradiol (E2), progesterone (PGN), follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels were investigated in hyperprolactinemic (hyperPRL) rats. The effect of FMD on PRL secretion, dopamine D2 receptor and dopamine transporters (DAT) were studied in MMQ cells derived from rat pituitary adenoma cells, GH3 cells derived from rat pituitary lactotropic tumoral cells and PC12 cells from rat pheochromocytoma, respectively.
Results: Compared with the model group, a high dose of FMD (11.6 g/kg body weight) and medium dose of FMD (5.8 g/kg body weight) reduced PRL level of hyperPRL rats effectively. In MMQ cells, treatment with 5 mg/ml FMD (p < 0.01) or 10 mg/mL FMD (p < 0.01) significantly suppressed PRL secretion and synthesis at 24 h compared with controls (p < 0.01). Consistent with D2- action, FMD did not affect PRL in rat pituitary lactotropic tumor-derived GH3 cells that lack the D2 receptor ex
Conclusion: FMD shows anti-hyperprolactinemia activity via dopamine D2 receptor.
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