Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Anti-hypertensive effect of Morus alba L extract in rats

Sheng-li Pei¹, Fang Kan², Chun-jiang Yue³

¹Nursing Department; ²Department of Neurosurgery; ³Department of Vasculocardiology, Tongren Hospital Affiliated to Wuhan University (The Third Hospital of Wuhan), Wuhan 430060, Hubei Province, China.

For correspondence:- Chun-jiang Yue Email: 1350794936@qq.com Tel:+8613971128500

Accepted: 22 May 2021 Published: 30 June 2021

Citation: Pei S, Kan F, Yue C. Anti-hypertensive effect of Morus alba L extract in rats. Trop J Pharm Res 2021; 20(6):1205-1209 doi: 10.4314/tjpr.v20i6.16

© 2021 The authors.
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Abstract

Purpose: To investigate the probable antihypertensive effects of Morus alba L. extract (MALE) in renovascular hypertensive rats, and the mechanism involved in the reduction of blood pressure.

Methods: The two-kidney one-clip (2K1C) Goldblatt model of renovascular hypertension was used in Wistar rats. The 2K1C group rats were treated with captopril (30 mg/kg), and Morus alba extract (75 and 150 mg/kg) daily for 6 weeks by intragastric administration. Systolic (SBP) and diastolic blood pressure (DBP) were measured by the tail-cuff method. Urine creatinine and urea of the rats were measured by enzyme-linked immunosorbent assay (ELISA). Superoxide dismutase (SOD) and malondialdehyde (MDA) were also evaluated using standard techniques.

Results: In the captopril- and extract-treated groups, blood pressure decreased progressively over the course of the 6-week treatment period compared with that of the control rats (p < 0.01). The extract at 150 mg/kg also significantly (p < 0.05) increased plasma SOD activity but decreased plasma MDA concentration. Renal function significantly (p < 0.01) improved following captopril and extract (150 mg/kg) treatment.

Conclusion: The results suggest that Morus alba extract exerts its antihypertensive effect in rats by inhibiting endothelin (ET)-converting enzyme and via its antioxidant activity. Thus, the plant extract has some potentials for development into a new drug in ffor use in humans.

Keywords: Antihypertensive, Morus alba, Goldblatt renovascular hypertension, Endothelin-1, Hypertrophy