Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Anti-hyperuricemic effect of Plantago depressa Willd extract in rats

Ning Xia¹, Bao-an Li², Hai-ju Liu³, Jiu-bo Fan⁴, Wei Shen¹, Xiu-guo He⁵

¹Department of Pharmacy, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science; ²Medicine of Xiangyang Vocational and Technical College; ³Department of Orthopaedics; ⁴Department of Clinical Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science; ⁵Department of Pharmacy, Suizhou Central Hospital, Affiliated Hospital of Hubei University of Medicine, Suizhou, Hubei Province, 441300 PR China.

For correspondence:- Xiu-guo He Email: hexiuguo133494@sina.com Tel:+867103528933

Received: 31 March 2016 Accepted: 8 May 2017 Published: 29 June 2017

Citation: Xia N, Li B, Liu H, Fan J, Shen W, He X. Anti-hyperuricemic effect of Plantago depressa Willd extract in rats. Trop J Pharm Res 2017; 16(6):1365-1368 doi: 10.4314/tjpr.v16i6.21

© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the effects of Plantago depressa Willd. extract (PDWE) on hyperuricemia in rats.

Methods: The effect of PDWE was investigated in hyperuricemic rats induced by potassium oxonate. PDWE were fed to hyperuricemic rats daily at a dose of 160, 320 and 640 mg/kg for 10 days; allopurinol (5 mg/kg) was given as positive control. Serum and urine levels of uric acid and creatinine were determined by colorimetric method.

Results: PDWE inhibited xanthine oxidase (XOD) activity in serum (16.36 ± 1.16 U/L, p < 0.05) and liver (72.15 ± 5.26 U/g protein, p < 0.05), and also decreased levels of serum uric acid (2.43 ± 0.59 mg/L, p < 0.05), serum creatinine (0.42 ± 0.15 µmol/L) and blood urea nitrogen (BUN, 9.58 ± 0.72 mmol/L, p < 0.05), but increased levels of urine uric acid (39.23 ± 8.22 mg/L, p < 0.05) and urine creatinine (32.24 ± 1.69 mmol/L, p < 0.05) in the renal tissue of hyperuricemic rats.

Conclusion: PDWE exerts uricosuric action by regulating renal urate transporters to ameliorate renal dysfunction in hyperuricemic rats.

Keywords: Plantago depressa Willd., Hyperuricemic, Renal urate transporters, Renal dysfunction, Uricosuric action