Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Anti-thrombolytic effect of Salvia miltiorrhiza Bge extract in rats

Jia Tian¹, Xiao-yan Wu², Mo-yang Zhang³, Zhong-yi Zhou¹, Ying-feng Liu²

¹Intensive Medical Unit, Hainan Provincial People's Hospital, Haikou 570010; ²Internal Medicine-Cardiovascular Department, Zhujiang Hospital affiliated to Southern Medical University, Guangzhou 510000; ³Rheumatism Department, Hainan Provincial People's Hospital, Haikou 570010, China.

For correspondence:- Ying-feng Liu Email: iuyingfeng133@sina.com Tel:+862061643864

Received: 15 April 2016 Accepted: 5 April 2017 Published: 30 May 2017

Citation: Tian J, Wu X, Zhang M, Zhou Z, Liu Y. Anti-thrombolytic effect of Salvia miltiorrhiza Bge extract in rats. Trop J Pharm Res 2017; 16(5):1085-1089 doi: 10.4314/tjpr.v16i5.16

© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To study the effects of Salvia miltiorrhiza Bge. extract (SMBE) on thrombosis in rats.

Methods: SMBE was obtained in water at 60 ^oC in an oven and then freeze-drying. Rats were divided into 6 groups of ten rats each: normal group, control group, reference group (aspirin 5 mg/kg) as well as three groups of SMBE groups (25, 50 and 100 mg/kg doses). Treatments were given orally once daily for 14 days. Common carotid artery FeCl₃-induced thrombus and inferior vena cava thrombosis occlusion time, plasma concentrations of thromboxane B2 (TXB2) and 6-keto-prostaglandine F1α (6-keto-PGF1α) were measured in the rats.

Results: Compared with control group, all doses of SMBE significantly and dose-dependently prolonged thrombosis occlusion time, reduced the weight of thrombus and increased the inhibition rate of thrombus (p < 0.01). Plasma TXB2 concentration of all SMBE groups decreased dose-dependently (p < 0.05) while that of 6-keto-PGF1α increased with decrease in extract dose (p < 0.05). There was association between 6-keto-PGF1α/TXB2 and arterial or venous thrombus weight for all treatments, and also with occlusion time for SMBE treatment, but not for aspirin.

Conclusion: The results demonstrate the anti-thrombosis effect of SMBE in rats. This finding suggests that the plant is a potential therapy for thrombosis

Keywords: Salvia miltiorrhiza Bge., Thrombosis, Thromboxane B2, 6-Keto-prostaglandin F1 alpha, Aspirin, Occlusion time