Tropical Journal of Pharmaceutical Research

Review Article | OPEN ACCESS

Anticancer potentials of sinomenine from Sinomenium acutum: A mini-review

Shuang Yang, Lan-Yu Peng, Wei Peng, Cong Huang, Da-Neng Wei, Mao-Ting Mou, Fang Liang

Chengdu University of Traditional Chinese Medicine, Chengdu610075, PR China;

For correspondence:- Fang Liang Email: gaoyxcdtcm@126.com Tel:+862861801001

Accepted: 20 November 2018 Published: 27 December 2018

Citation: Yang S, Peng L, Peng W, Huang C, Wei D, Mou M, et al. Anticancer potentials of sinomenine from Sinomenium acutum: A mini-review. Trop J Pharm Res 2018; 17(12):2519-2526 doi: 10.4314/tjpr.v17i12.30

© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Sinomenine, an important isoquinoline from Sinomenium acutum (Menispermaceae), is currently considered as a reliable drug for treating various malignant cancers including breast cancer, colon cancer, lung cancer, liver cancer, gastric cancer, osteosarcoma cervical cancer, and esophageal cancer. The pharmacological mechanisms are probably related to induction of apoptosis and cell cycle arrest. This paper was aimed at reviewing the anticancer potential of sinomenine, which is expected to be beneficial in developing this compound as a candidate drug for cancer therapy.

Keywords: Sinomenine, Anticancer, Sinomenium acutum, Traditional Chinese Medicine