Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Antimicrobial activity of the ethanol extract of the aerial parts of sida acuta burm.f. (malvaceae)

I E Oboh¹, J O Akerele² , O . Obasuyi²

¹Department of Pharmacognosy, University of Benin ,Benin City, Nigeria.; ²Department of Pharmaceutical Microbiology, University of Benin ,Benin City, Nigeria..

For correspondence:- J Akerele Email: akerelej@uniben.edu

Published: 25 December 2007

Citation: Oboh IE, Akerele JO, Obasuyi O.. Antimicrobial activity of the ethanol extract of the aerial parts of sida acuta burm.f. (malvaceae). Trop J Pharm Res 2007; 6(4):809-813 doi: 10.4314/tjpr.v6i4.3

© 2007 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: The antimicrobial activity of the 90 % ethanol extract of the aerial parts of Sida acuta Burm. F. (Malvaceae) was investigated in other to verify its claimed ethno medicinal use in the treatment of microbial infections.

Method: The antimicrobial activity of the extract was tested against standard strains and clinical isolates of some aerobic bacteria and a fungus using the Agar well diffusion method. Commercial antibiotics were used as positive reference standards to determine the sensitivity of the strains.

Results: The extracts showed significant inhibitory activity against standard strains and clinical isolates of Staphylococcus aureus, clinical isolates of Bacillus subtilis and Streptococcus faecalis. The MIC values obtained using the Agar-dilution test ranged from 5.0 mg/ml. – 10.0 mg/ml. Neither the concentrated extract nor its dilutions inhibited Esherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Candida albicans.

Conclusion: The results demonstrate that the crude extract of the aerial parts of Sida acuta has a narrow spectrum of activity and suggest that it may be useful in the treatment of infections caused by Gram positive aerobic bacteria.

Keywords: Sida acuta, ethanol extract, antimicrobial activity.