Tsun-Thai Chai1,2 
,
Mirohsha Mohan2,
Hean-Chooi Ong3,
Fai-Chu Wong1,2
For correspondence:- Tsun-Thai Chai Email: chaitt@utar.edu.my Tel:+6054688888
Received: 1 February 2013 Accepted: 21 November 2013 Published: 25 January 2014
Citation: Chai T, Mohan M, Ong H, Wong F. Antioxidant, Iron-chelating and Anti-glucosidase Activities of Typha domingensis Pers (Typhaceae). Trop J Pharm Res 2014; 13(1):67-72 doi: 10.4314/tjpr.v13i1.10
© 2014 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To evaluate the phytochemical profile as well as in vitro antioxidant, iron-chelating, and anti-glucosidase activities of Typha domingensis Pers. (Typhaceae).
Methods: Total polyphenols, flavonoids, hydroxycinnamic acids, and pro-anthocyanidins in the respective aqueous extracts of male and female flowers, and fruit of T. domingensis were determined by established procedures. Antioxidant activity was evaluated by superoxide anion radical and nitric oxide scavenging assays. Iron chelating activity was assessed using a ferrozine-based assay. Anti-glucosidase activity was determined using 4-nitrophenyl a-D-glucopyranoside as a substrate.
Results: Phenolic contents decreased in the following order: fruit > female flower > male flower. Superoxide scavenging half-maximal effective concentration (EC50) of fruit, female flower and male flower extracts was 3.5, 4.8, and 28.2 mg dry matter (DM)/ml, respectively, while nitric oxide scavenging EC50 of fruit, female flower and male flower extracts was 0.16, 0.65, and 0.95 mg DM/ml, respectively. On the other hand, iron chelating EC50 of female flower, male flower and fruit extracts was 4.86, 6.43, and 10.88 mg DM/ml, respectively. Only the fruit and female flower extracts exhibited anti-glucosidase activity, with EC50 of 0.75 and 5.07 mg DM/ml, respectively.
Conclusion: The fruit and female flower extracts of T. domingensis are promising sources of natural antioxidants, iron chelators, and glucosidase inhibitors.
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