Marina L do C Caxito1,2,
Cristiane P Victório1,3
,
Helber B da Costa4,
Wanderson Romão4,5,
Ricardo M Kuster2,
Cerli R Gattass1
1Instituto de BiofÃsica Carlos Chagas Filho;
2Instituto de Pesquisas de Produtos Naturais, Bloco H, CCS, Universidade Federal do Rio de Janeiro, 21941-902;
3Laboratório de Pesquisa em Biotecnologia Ambiental, Fundação Centro Universitário Estadual da Zona Oeste-UEZO, Av. Manoel Caldeira de Alvarenga 1203, 23070-200, Campo Grande, Rio de Janeiro;
4Núcleo de Competência em QuÃmica do Petróleo, Universidade Federal do EspÃrito Santo, Av. Fernando Ferrari, 514, 29075-910, Vitória, EspÃrito Santo;
5Instituto Federal de Educação, Ciência e Tecnologia do EspÃrito Santo, Campus Vila Velha, Avenida Ministro Salgado Filho, 1000, 29106-010, Soteco, Vila Velha, Brazil.
For correspondence:- Cristiane Victório
Email: cristianevictorio@uezo.rj.gov.br
Received: 14 March 2017
Accepted: 26 April 2017
Published: 30 May 2017
Citation:
Caxito ML, Victório CP, Costa HB, Romão W, Kuster RM, Gattass CR.
Antiproliferative activity of extracts of Euphorbia tirucalli L (Euphorbiaceae) from three regions of Brazil. Trop J Pharm Res 2017; 16(5):1013-1020
doi:
10.4314/tjpr.v16i5.7
© 2017 The authors.
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Abstract
Purpose: To investigate Euphorbia tirucalli extract for probable geographic variations in its antiproliferative activity.
Methods: The aerial parts of E. tirucalli were collected in the Brazilian states of Mato Grosso, Rio de Janeiro, Pará, Minas Gerais and Santa Catarina. The 70 % ethanol extract was obtained according to the procedure described in Brazilian Homeopathic Pharmacopeia. The antiproliferative activity of extracts, in concentrations of 62, 125, 250, and 500 µg mL-1, was tested against leukemia (HL-60), lymphoma (Daudi) and melanoma (B16F10) cell lines using methyl thiazol tetrazolium assay (MTT). Phytochemical analysis were carried out using High-performance liquid chromatography-diode array (HPLC-UV-DAD) and electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI(-) FT-ICR MS) assays.
Results: There was significant regional variability in the cytotoxicity of E. tirucalli extracts in a dose-dependent manner. The extracts had similar activity towards leukemia cell line HL-60, decreasing cell viability to about 60 – 70 %. The extract showed the presence of ellagitannins, flavonoids, veracylglucan, and acid triterpenes as the major compounds.
Conclusion: While the results support the ethnopharmacological use of E. tirucalli throughout Brazil, regional quantitative differences found in some classes of secondary metabolites may explain the variations observed in antitumor activity
Keywords: Aveloz, Cancer, Cytotoxicity, Antiproliferative, Ethnopharmacological, Traditional medicine