Huan Wu1,
Jialing Xu1,
Yufeng Wen1 
,
Xia Dan1,
Mengxue Liu1,
Jun Ma1,
Zewei Wu1,
Hua Dong2
For correspondence:- Yufeng Wen Email: wyf2015w@sina.com Tel:+865533932059
Received: 22 January 2017 Accepted: 19 July 2017 Published: 31 August 2017
Citation: Wu H, Xu J, Wen Y, Dan X, Liu M, Ma J, et al. Association between cystatin C and the interaction of pulmonary tuberculosis with chronic diseases. Trop J Pharm Res 2017; 16(8):2007-2012 doi: 10.4314/tjpr.v16i8.34
© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To determine the association between Cystatin C (Cys C) levels and the interaction of pulmonary tuberculosis (PTB) with chronic diseases (CD).
Methods: Participants (n = 356) were selected randomly from The First Affiliated Hospital of Wannan Medical College, China, and divided into 4 groups: normal control group (n = 80), PTB group (n = 98), chronic disease group (n = 146), and PTB combined with chronic disease group (PTB+CD, n = 31). The investigation included information on demographics and analysis of blood samples for Cys C, liver function, renal function, blood glucose and other biochemical indices.
Results: The highest level of Cys C was obtained in PTB + CD group. Before and after adjusting eGFR, there was no association between Cys C and PTB or/and chronic disease. However abnormal levels of Cys C were significantly higher in PTB+CD group after adjusting eGFR (OR = 4.014, p = 0.0125).
Conclusion: Higher levels of Cys C may be associated with chronic diseases co-existing with PTB.
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