Jitendra H Vaghela1,
Vishalkumar K Vadgama2,
Bhargav M Purohit2 
For correspondence:- Bhargav Purohit Email: drbhargavpurohit@gmail.com Tel:+919725024978
Accepted: 22 January 2020 Published: 30 April 2020
Citation: Vaghela JH, Vadgama VK, Purohit BM. Bronchodilatory effect of Zingiber officinale Roscoe (ginger) in guinea pigs. Trop J Pharm Res 2020; 19(4):845-849 doi: 10.4314/tjpr.v19i4.24
© 2020 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To determine the bronchodilatory effect of ginger on histamine-induced bronchospasm in guinea pigs.
Methods: Thirty-six guinea pigs weighing 400 - 700 g were randomly divided into six groups. Group 1 received distilled water, while group 2 was given formoterol (1.55 µg/kg) + budesonide (0.02 mg/kg). Guinea pigs in groups 3 and 4 were given ginger (350 and 700 mg/kg, respectively), while those in groups 5 and 6 received ginger (350 and 700 mg/kg, respectively) in addition to formoterol (1.55 µg/kg) and budesonide (0.02 mg/kg). Pre-convulsion time and percent protection in each group was calculated.
Results: There was statistically significant improvement in pre-convulsion times, with values of 156.64 ± 32.93, 299.33 ± 44.20, and 235.99 ± 34.55 s for groups 2, 5 and 6, respectively (p < 0.01). Moreover, statistically significant protection values of 73 and 68 % were obtained for groups 5 and 6, respectively, relative to normal control (p < 0.01).
Conclusion: These results indicate that ginger has promising potential for use as an add-on treatment for bronchospasm.
Archives
News Updates
Fulltext in PDF