Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Carboprost tromethamine prevents caesarean section-associated postpartum hemorrhage

Li Wang , Hong-mei Jiang, Rui-rui Yang

Binzhou People's Hospital, Shandong 256600, PR China;

For correspondence:- Li Wang Email: wanglioss@163.com

Accepted: 29 January 2020 Published: 30 April 2020

Citation: Wang L, Jiang H, Yang R. Carboprost tromethamine prevents caesarean section-associated postpartum hemorrhage. Trop J Pharm Res 2020; 19(4):899-904 doi: 10.4314/tjpr.v19i4.32

© 2020 The authors.
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Abstract

Purpose: To investigate the effect of carboprost tromethamine on post-partum hemorrhage associated with caesarean section.

Methods: One hundred patients with postpartum hemorrhage induced by cesarean section who were admitted to Binzhou People’s Hospital from October 2016 to August 2018 were selected. They were randomly assigned to two groups: control group and treatment group. Patients in the control group were administered oxytocin, while those in the treatment group received oxytocin in combination with carboprost tromethamine. The incidence of hemorrhage and adverse reactions were compared for the two groups.

Results: The two groups showed gradually increasing degrees of postpartum hemorrhage within 24 h, but the treatment group had significantly lower volume of postpartum hemorrhage than the control group at different time points (p < 0.05). At the 1st, 3rd and 5th days after delivery, the height of the uterine fundus decreased gradually in the two groups, but was smaller in the treatment group than in the oxytocin group at all time points (p < 0.05). Total response in the treatment group was 98 %, which was significantly higher than 78 % in the control group (p < 0.05). The incidence of adverse reactions in the treatment group (12 %) was significantly lower than that in the control group (24 %, p < 0.05).

Conclusion: Carboprost tromethamine prevents postpartum hemorrhage after cesarean section. It effectively reduces bleeding and promotes uterine involution, without obvious adverse reactions.

Keywords: Carboprost tromethamine, Oxytocin, Cesarean section, Postpartum hemorrhage