Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Challenges in chemotherapy-induced nausea and vomiting (CINV) management: A systematic review

Nurul Suhaida Badarudin¹, Noraida Mohamed Shah¹ , Fuad Ismail², Farida Islahudin¹, Nurul Ain Mohd Tahir¹

¹Centre of Quality Management of Medicines, Faculty of Pharmacy, Universiti Kebangsaan Malaysia; ²Department of Radiotherapy and Oncology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.

For correspondence:- Noraida Shah Email: noraida_mshah@ukm.edu.my

Accepted: 7 March 2024 Published: 31 March 2024

Citation: Badarudin NS, Shah NM, Ismail F, Islahudin F, Tahir NA. Challenges in chemotherapy-induced nausea and vomiting (CINV) management: A systematic review. Trop J Pharm Res 2024; 23(3):653-668 doi: 10.4314/tjpr.v23i3.21

© 2024 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To systematically evaluate evidence regarding the barriers and challenges associated with chemotherapy-induced nausea and vomiting (CINV).

Methods: The databases Pubmed, Ovid, Scopus, Cochrane Library, Wiley Online, and Web of Science were searched using the following keywords: challenges, prevention, CINV, chemotherapy and their corresponding alternative keywords. This review included all studies involving adult cancer patients receiving chemotherapy exclusively, the caretaker, and healthcare professionals handling cancer patients, without geographical restriction. The articles used were in English language and were original primary studies. The data extraction form was developed based on PRISMA guide. The Joanna Briggs Institute (JBI) Critical Appraisal tool was used to assess the quality of the studies.

Results: From 1,170 related articles retrieved, 38 were included in this review of which 9 articles were from European countries while 7 were from the United States of America. All articles met the criterion of the JBI critical appraisal. The reviews indicated that the barriers and challenges reported in the management of CINV would include failure to adhere to the antiemetic guideline, misconception about CINV and its prevention, and nausea and delayed CINV.

Conclusion: Interventions such as enhancing nausea and delayed vomiting control, raising awareness of antiemetic guidelines among healthcare professionals, and dispelling misconceptions need to be planned and implemented to overcome the barriers and challenges and improve the quality of CINV management.

Keywords: Chemotherapy-induced nausea and vomiting (CINV), Nausea, Vomiting, Supportive care, Anti-emetic