Yuanyuan Wang , Jihong Deng, Shizhen Liu, Jinping Tan, Zhimin Chen

For correspondence:-  Yuanyuan Wang   Email: racheal818@163.com

Accepted: 13 August 2024        Published: 30 September 2024

Citation: Wang Y, Deng J, Liu S, Tan J, Chen Z. Comparison of two types of thrombolysis combined with percutaneous transluminal angioplasty for acute thrombosis in arteriovenous fistula and graft. Trop J Pharm Res 2024; 23(9):1517-1523 doi: 10.4314/tjpr.v23i9.15

© 2024 The authors.
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Abstract

Purpose: To investigate and compare the efficacy of two different types of thrombolysis combined with percutaneous transluminal angioplasty (PTA) for acute thrombosis in arteriovenous fistula (AVF) and graft (AVG). Methods: A total of 128 patients on hemodialysis with acute AVF/AVG occlusion, from May 2021 to May 2023 at Jiangmen Central Hospital, Guangdong, were randomly assigned to study group (catheter-directed thrombolysis) (CDT) comprising of 62 patients and control group (scalp needle thrombolysis) comprising of 66 patients. Patients whose thrombolysis was unsuccessful on the first day, received PTA therapy the next day. Thrombolytic success rates, urokinase dosage, PTA therapy rates, mural thrombus occurrence, and post-thrombolytic complications were evaluated and compared. Result: There was no significant difference in overall thrombolytic success rate, PTA combination rate and incidence of hemorrhage (p > 0.05) between study and control groups. Recanalization rate after urokinase thrombolytic therapy on first day was significantly higher in the study group than in the control group (p < 0.05). Urokinase dosage (first day) of patients whose thrombolytic therapy was successful was significantly lower in the study group than in the control group (p < 0.001). Conclusion: Mechanical fragmentation by angiography catheter combined with urokinase thrombolysis improves efficacy, but shows no advantage when combined with PTA. Additional studies using a larger patient population on anticoagulant therapy and longer investigation time are recommended to enhance the generalizability of this treatment approach.