Hao Wang,
Wenxian Zhang,
Bin Jiang 
For correspondence:- Bin Jiang Email: b5hnox@163.com
Accepted: 15 December 2019 Published: 31 January 2020
Citation: Wang H, Zhang W, Jiang B. Constipation-relieving effect of L-arabinose. Trop J Pharm Res 2020; 19(1):95-99 doi: 10.4314/tjpr.v19i1.15
© 2020 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the mitigating effect of L-arabinose on constipation in a mouse model of experimental constipation.
Methods: Kunming mice were used as experimental animals to establish a constipation model. Intestinal propulsion, first defecation time, number of defecation pellets, and the weight of defecation pellets in 5 h were measured. L-Arabinose was given at 3 dose levels, viz, low dose (0.5 g/kg/day), medium dose (0.75 g/kg/day), and high dose (2.5 g/kg/day), and their effects on constipation were compared with that of the model control group.
Results: Compared with the model control group, there were significant differences in ink propulsion (F = 22.67, p < 0.05); time taken for first black stool to appear (F = 19.51, p < 0.05), number of fecal pellets (F = 12.22, p < 0.05), and fecal weight (F = 5, p < 0.05) in the L-arabinose groups.
Conclusion: L-Arabinose relieves constipation symptoms in an experimental mouse model of constipation. Therefore, L-arabinose may be useful in the management of patients with constipation, but further studies in humans are required to ascertain this.
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