Meiling Sheng1, Ruju Xu1, Xiangying Wang1, Yanyan Zhu1, Chunli Zhang2
1Department of Pediatric Rheumatology and Immunology, Hangzhou Children’s Hospital, No. 195 Wenhui Road, Gongshu District, Hangzhou, Zhejiang 310005,; 2Department of Pediatric Cardiology, Hangzhou Children’s Hospital, No. 195 Wenhui Road, Gongshu District, Hangzhou, Zhejiang, 310005, China.For correspondence:- Chunli Zhang Email: zhang15167640095@163.com Tel:+86-0571-85465456
Received: 4 January 2024 Accepted: 19 September 2024 Published: 29 October 2024
Citation: Sheng M, Xu R, Wang X, Zhu Y, Zhang C. Curcumin alleviates asthma in rat by targeting Foxp3. Trop J Pharm Res 2024; 23(10):1623-1629 doi: 10.4314/tjpr.v23i10.5
© 2024 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To examine the mitigating influence of curcumin on asthma in children, and the involvement of Foxp3 in the process. Methods: A rat model of asthma was successfully induced using ovalbumin (OVA). Twenty-four (24) rats were assigned to 3 cohorts: model, curcumin and control groups. At the cellular level, sorted CD4+ T cells were differentiated into regulatory T (Treg) cells and divided into 4 groups: Treg, Treg + curcumin, Treg + STAT5-IN-1 (STAT5 inhibitor) and Treg + curcumin + STAT5-IN-1 groups. Results: Curcumin significantly inhibited OVA-induced increases in eosinophils and lymphocytes and reduced airway pathological changes, relative to model rats (p < 0.05). There were marked increases in TGF-β and IL-10 contents in bronchial alveolar lavage fluid (BALF), relative to model rats. Furthermore, curcumin up-regulated p-STAT5 and Foxp3 in the lung tissues of rats, when compared with model group (p < 0.05). In cell experiments, curcumin significantly increased p-STAT5, Foxp3 and IL-10 levels, and enhanced the transformation of CD4+ T cells to more Treg cells (p < 0.05). Conclusion: Curcumin may affect the differentiation of Treg cells, as well as alleviate asthma in rats by targeting Foxp3 through STAT5 regulation. This research has identified the likely beneficial role of curcumin as therapeutic agent for pediatric asthma, but this has to be clinically validated
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