Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Design Optimization and Evaluation of Gastric Floating Matrix Tablet of Glipizide

Lalit Singh¹ , Arun Nanda², Saurabh Sharma³, Vijay Sharma¹

¹Department of Pharmaceutics, SRMSCET, Pharmacy, Bareilly, Uttar Pradesh; ²Department of Pharmaceutical Sciences MDU, Rohtak, Haryana; ³Vivek College of Technical Education, Bijnor, Uttar Pradesh, India.

For correspondence:- Lalit Singh Email: lalit4u78@rediffmail.com Tel:+919412602860

Received: 5 October 2012 Accepted: 11 October 2013 Published: 24 December 2013

Citation: Singh L, Nanda A, Sharma S, Sharma V. Design Optimization and Evaluation of Gastric Floating Matrix Tablet of Glipizide. Trop J Pharm Res 2013; 12(6):869-876 doi: 10.4314/tjpr.v12i6.2

© 2013 The authors.
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Abstract

Purpose: To formulate an optimized gastric floating drug delivery system (GFDDS) containing glipizide with carbomers and cellulosic polymers.

Method: Central composite design (CCD) was employed in formulating the GFDDS using hydroxypropyl methylcellulose K4M (HPMC K4M) (A) and Carbopol 934P (CP934P) (B), as independent variables. Floating lag time (FLT), total floating time (TFT) and time required to release 50 % of the drug (T₅₀) were selected as dependent variables. The dissolution data obtained were fitted to various release models and the floating profiles of the formulations analyzed.

Results: HPMC K4M loading clearly enhanced floating properties while CP934P showed negative effect on floating properties but was helpful in controlling drug release. The quadratic mathematical model developed was used to predict optimum formulations. The computer optimization process, contour plots and response surface plots predicted the concentration of independent variables A and B to be 47.32 and 8.4 mg, respectively, for maximum TFT and T₅₀ at the same time for least FLT. Predicted concentration of independent variables showed the same results experimentally, with -0.75 - 1.47 percentage errors.

Conclusion: CCD demonstrated the role of the derived equations, contour plots and response surface plots in predicting the values of independent variables for the preparation and optimization of glipizide gastric floating matrix tablet.

Keywords: Effervescent, Floating tablet, Design of Experiment, Release kinetics, Central composite design, Optimization