Muhammad Zaman1
,
Rai Muhammad Sarfraz2,
Sherjeel Adnan1,
Asif Mahmood2,
Muhammad Hanif3,
Junaid Qureshi4,
Muhammad Taimoor Chaudhary5,
Muhammad Abdullah Akram6,
Irfan Bashir7
1Faculty of Pharmacy, The University of Lahore, Lahore;
2Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur;
3Faculty of Pharmacy, Bahauddin Zakaryia University, Multan;
4Faculty of Pharmacy G.C. University Faisalabad, Faisalabad;
5Punjab Forensic Science Agency, Toxicology Unit, Lahore, Pakistan;
6Faculty of Pharmacy University of Sargodha, Sargodha, Pakistan;
7Faculty of Pharmacy University of Central Punjab, Lahore, Pakistan.
For correspondence:- Muhammad Zaman
Email: m.zaman2157@gmail.com Tel:+923006095928
Received: 2 October 2014
Accepted: 28 June 2015
Published: 29 September 2015
Citation:
Zaman M, Sarfraz RM, Adnan S, Mahmood A, Hanif M, Qureshi J, et al.
Development and in-vitro evaluation of once daily tablet dosage form of loxoprofen sodium. Trop J Pharm Res 2015; 14(9):1557-1563
doi:
10.4314/tjpr.v14i9.3
© 2015 The authors.
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Abstract
Purpose: To formulate and characterize once daily controlled release tablet of loxoprofen sodium.
Methods: Eudragit RS-100, hydroxylpropyl methylcellulose (HPMC) and pectin were used as release retarding polymers. All the formulations were prepared by direct compression method. Various pre-compression studies were carried out to determine Hausner’s ratio, Carr’s index, angle of repose, bulk density and tapped density Differential scanning calorimetry (DSC) studies and also post-compression studies to evaluate hardness, friability, weight variation, drug content, in-vitro drug release were conducted on the tablets. The drug release data were subjected to kinetic models, including zero order, first order, Hixon Crowell, Higuchi and Korsmeyer-Peppas.
Results: Compressibility index (7.6 ± 1.32 - 12.5 ± 1.43%), Hausner’s ratio (1.08 ± 0.04 - 1.14 ± 0.03), angle of repose (27.78 ± 0.47 - 30.49 ± 0.46°), hardness (6.25 ± 0.27 - 7.21±0.21 kg/cm2), friability (0.14 ± 0.06 - 0.28 ± 0.0 %), weight variation (249.5 ± 2.09 - 251.35 ± 2.41 mg) and drug content (97.30 ± 0.28 - 103.70 ± 0.31 %) were within generally accepted limits for the pre-and post-compression formulations, respectively. The tablets having the maximum amount of among the three polymers tested as matrix materials, HPMC, represented by F3 tablets, exerted better sustained release properties after 12 h. Release pattern was more of Fickian diffusion followed by Higuchi mechanism.
Conclusion: The release of the loxoprofen sodium was optimized up to 12 h.
Keywords: Loxoprofen, Sustained release, hydroxypropyl methylcelluose, Pectin, Eudragit, Matrix tablets