Ying Zhang,
Zhenya Zhang 
,
Yinnan Yang,
Xiaoyan Zu,
Di Guan,
Yuepeng Wang
For correspondence:- Zhenya Zhang Email: tyou6688@sakura.cc.tsukuba.ac.jp Tel:+81298534712
Received: 2 February 2011 Accepted: 14 May 2011 Published: 24 June 2011
Citation: Zhang Y, Zhang Z, Yang Y, Zu X, Guan D, Wang Y. Diuretic Activity of Rubus idaeus L (Rosaceae) in Rats. Trop J Pharm Res 2011; 10(3):243-248 doi: 10.4314/tjpr.v10i3.15
© 2011 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To evaluate the diuretic activity of Rubus idaeus L in experimental rats.
Methods: Hot-water and methanol extract of three kinds of Rubus idaeus L. fruits were administered to experimental rats orally at a dose of 2 and 5 mg/kg. Hydrochlorothiazide (10 mg/kg) was used as positive control in study. The diuretic effect of the extracts was evaluated by measuring urine volume, sodium and potassium excretion in the urine.
Results: Compared with the control group, significant increase in urine volume was observed from the experimental animal treated with wild raspberry methanol extract. In addition, we find that the methanol extract of wild raspberry fruits shows a potassium-conservation diuretic effect, which is a very interesting property in a phytodiuretic.
Conclusion: Methanol extract of wild raspberry fruits have diuretic effect on experimental rats. This might be the first formal reports on diuretic effect of raspberry fruits, which can also, to some extent, explain the use of raspberry as a cure for renal diseases in Chinese traditional medical practice.
Archives
News Updates
Fulltext in PDF