Hasan Çalıskan1,2 
,
Koray Hamza Cihan3,
Emel Günes1,
Ahmet Ergün1,
Mitat Can Öztürk3,
Sükrü Hakan Gençer3,
Süleyman Kılınç3,
Zakir Osmanov3,
Mehmet Oguzhan Kaya3,
Murat Kılıçdagi3
For correspondence:- Hasan Çalıskan Email: hasanmonica@hotmail.com Tel:+903125958272
Accepted: 31 October 2019 Published: 30 November 2019
Citation: Çalıskan H, Cihan KH, Günes E, Ergün A, Öztürk MC, Gençer SH, et al. Duloxetine alleviates high light-induced anxiety-related behaviors in Wistar rats. Trop J Pharm Res 2019; 18(11):2319-2323 doi: 10.4314/tjpr.v18i11.13
© 2019 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the effect of subchronic duloxetine treatment on high light-induced anxiety-related behaviors in Wistar rats.
Methods: Adult male Wistar rats (n = 30) were randomly assigned to three groups of rats (10 rats/group): control group, 30 mg/kg duloxetine group, and 60 mg/kg duloxetine group. Intraperitoneal injection of duloxetine was given once a day for ten days. The anxiolytic effect of duloxetine in the rats was assessed using light/dark box (LDB) anxiety test.
Results: Anxiety-related behaviors were significantly reduced in duloxetine-treated rats, when compared with control group. The reductions were not dose-dependent (light zone time and latency time were significantly increased, while dark zone time decreased significantly, p < 0.05). The number of rearings significantly increased in 30 mg/kg duloxetine group, relative to control and 60 mg/kg duloxetine groups (p < 0.05). However, there were no significant differences in the number of light-to-dark entrances among the groups (p > 0.05).
Conclusion: These results show that subchronic treatment with duloxetine alleviates anxiety-related behaviors in Wistar rats.
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