Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of Mucuna pruriens (Linn.) on Global Cerebral Ischemia-induced Motor Incoordination

Vanishri S Nayak¹, KSR Pai², Sunil S Nayak³ , Nitesh Kumar², Hemalatha Bangera⁴

¹Department of Anatomy, Kasturba Medical College; ²Department of Pharmacology, Manipal College of Pharmaceutical Sciences; ³Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal; ⁴Department of Anatomy, Father Muller Medical College, Mangaluru, Karnataka, India.

For correspondence:- Sunil Nayak Email: sunil.nayak@manipal.edu

Accepted: 19 May 2021 Published: 30 June 2021

Citation: Nayak VS, Pai K, Nayak SS, Kumar N, Bangera H. Effect of Mucuna pruriens (Linn.) on Global Cerebral Ischemia-induced Motor Incoordination. Trop J Pharm Res 2021; 20(6):1193-1198 doi: 10.4314/tjpr.v20i6.14

© 2021 The authors.
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Abstract

Purpose: To evaluate the effect of Mucuna pruriens on ischemia-induced motor incoordination.

Methods: Male Wistar rats were used in this study were divided into eight groups of six rats each. The bilateral common carotid artery (BCA) was occluded to induce global cerebral ischemia. Carboxymethylcellulose (CMC) was used as a vehicle for this while quercetin was used as the standard. The rats were fed with the methanol plant extract of Mucuna pruriens (MP) seeds for ten days. The treatment groups include treatment plus BCA occlusion. Various behavioral parameters such as locomotor activity, motor coordination, spatial learning, and cerebral infarction area were evaluated.

Results: A decline in locomotor activity, motor coordination, and spatial learning was observed in the ischemia-induced Wistar rats. The group treated with Mucuna pruriens showed significant protection against brain damage when compared with negative control group.

Conclusion: Mucuna pruriens provides effective neuroprotective activity in BCA occlusion-induced cerebral ischemia in rats, and thus a potential therapeutic agent for the clinical management of cerebral ischemia.

Keywords: Global ischemia, Mucuna pruriens, Oxidative stress, Brain damage, Locomotor activity, Motor coordination