Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of Taoren-Quyu decoction on endometriosis in rats

Ye Jin, Jian-hua Zheng

Department of Gynecology and Obstetrics, Women's Hospital School of Medicine Zhengjiang University, Hangzhou, 310006, Zhejiang Province, China;

For correspondence:- Jian-hua Zheng Email: zhengjianhua0451@126.com Tel:+8645185556024

Accepted: 5 May 2019 Published: 31 May 2019

Citation: Jin Y, Zheng J. Effect of Taoren-Quyu decoction on endometriosis in rats. Trop J Pharm Res 2019; 18(5):1057-1060 doi: 10.4314/tjpr.v18i5.20

© 2019 The authors.
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Abstract

Purpose: To study the effect of traditional Chinese Medicine formula Taoren-Quyu decoction (TQD) on endometriosis.

Method: Fifty female Wistar rats were randomly separated into five groups (10 rats/group): normal control, model (untreated) group, positive control (danazol), 200 mg/kg/day (low dose) or 400 mg/kg/day (high dose). All rats were prepared into endometriosis except for normal control rats. TDQ groups rats were orally administered of TQD for 5 weeks. After treatment, the rats were sacrificed by cervical dislocation. The number of total endometriotic lesions were counted. Serum levels of cancer antigen 125 (CA-125), interleukin 13 (IL-13), interleukin 18 (IL-18) and peritoneal fluid tumor necrosis factor-alpha (TNF-α) were measured by ELISA kits.

Result: Compared with control rats, TQD reduced the number of total endometriotic lesions significantly (12.7 ± 1.2, p < 0.01), as well as serum levels of CA-125 (6.4 ± 1.2 U/mL), IL-18 (118.6 ± 7.4 pg/mL), IL-13 (6.3 ± 0.8 pg/mL) and peritoneal fluid TNF-α (231.5 ± 11.7 pg/mL) (p < 0.01).

Conclusion: The results reveal that TQD exerts anti-endometriotic effect in rats by inhibiting inflammatory factors. Therefore, TQD has potentials for use in the treatment of endometriosis.

Keywords: Taoren-Quyu decoction, Endometriosis, Cancer antigen, Endometriotic lesions, Matrix metalloproteinase