Tropical Journal of Pharmaceutical Research

Review Article | OPEN ACCESS

Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 1)

Soheyla Honary , Foruhe Zahir

Mazandaran University of Medical Sciences, School of Pharmacy, Sari, Iran;

For correspondence:- Soheyla Honary Email: shonary@yahoo.com

Received: 17 August 2012 Accepted: 3 January 2013 Published: 24 April 2013

Citation: Honary S, Zahir F. Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 1). Trop J Pharm Res 2013; 12(2):255-264 doi: 10.4314/tjpr.v12i2.19

© 2013 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Zeta potential is a scientific term for electrokinetic potential in colloidal systems which has a major effect on the various properties of nano-drug delivery systems. Presently, colloidal nano-carriers are growing at a remarkable rate owing to their strong potential for overcoming old challenges such as poor drug solubility and bioavailability. Furthermore, they show an unlimited capacity in the field of drug targeting. The properties of nano-medicines such as release from dosage forms at specific sites as well as drug circulation and absorption into body membranes are dramatically affected by some physical and chemical characteristics of nano-drugs. Particle size and charge are two major factors which could play key roles in this regard. In this paper, the effect of zeta potential on different properties of nano-drug delivery systems is reviewed.

Keywords: Nano-drug delivery, Zeta potential, Drug targeting, Particle size, Particle charge