Tropical Journal of Pharmaceutical Research

Review Article | OPEN ACCESS

Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 2)

Soheyla Honary , Foruhe Zahir

Mazandaran University of Medical Sciences, School of Pharmacy, Sari, Iran;

For correspondence:- Soheyla Honary Email: shonary@yahoo.com

Received: 18 August 2012 Accepted: 7 January 2013 Published: 24 April 2013

Citation: Honary S, Zahir F. Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 2). Trop J Pharm Res 2013; 12(2):265-273 doi: 10.4314/tjpr.v12i2.20

© 2013 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

The zeta potential (ZP) of colloidal systems and nano-medicines, as well as their particle size exert a major effect on the various properties of nano-drug delivery systems. Not only the stability of dosage forms and their release rate are affected but also their circulation in the blood stream and absorption into body membranes are dramatically altered by ZP. In this paper the effect of ZP on the various properties of nano-medicines are reviewed. Furthermore, the ability of employing zeta potential to target drug delivery systems to, and drug release at specific sites of the body are discussed.

Keywords: Nano-medicines, Zeta potential, Drug targeting, Site-specific release, Dosage form stability