Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of Zicao ointment on second-degree burns in rats

Hong-bin Luo¹, Yi Cao¹, Mao-can Tao¹, Xiao-hong Yang¹, You-li Wang²

¹Department of Dematology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310000; ²Department of Dematology, Zhuji Hospital of Traditional Chinese Medicine, Zhuji 311800, Zhejiang Province, China.

For correspondence:- You-li Wang Email: wangyouli494@sina.com Tel:+8657587979091

Received: 21 June 2016 Accepted: 5 March 2017 Published: 30 April 2017

Citation: Luo H, Cao Y, Tao M, Yang X, Wang Y. Effect of Zicao ointment on second-degree burns in rats. Trop J Pharm Res 2017; 16(4):873-876 doi: 10.4314/tjpr.v16i4.18

© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the healing effect of Zicao Ointment (ZCO) on second-degree burns in rats.

Methods: Male Sprague Dawley (SD) rats, weighing 200 – 220 g, were subjected to deep second-degree skin burns by electrical scald instrument. The animals were divided into three groups as follows: (1) second-degree burns (control) group, (2) burns treated with 1 % silver sulfadiazine (SSD) group, and (3) second-degree burns treated with ZCO group. On days 3, 7 and 14 following administration of the drug or ZCO, wound area and histopathological changes of rat epidermis were evaluated for the various groups.

Results: On day 14, mean wound area of ZCO treatment group (0.28 ± 0.04 cm²) was significantly smaller than that of the control rats (2.63 ± 0.19 cm², p < 0.01). Histological results indicate that inflammatory cells disappeared and were replaced by new granulation tissue by day 14 in the group treated with ZCO. Compared with SSD group rats, the inflammatory cells decreased and fibroblast and granulation tissues increased significantly in burnt rats treated with ZCO.

Conclusion: Zicao Ointment is effective for the treatment of second-degree burns in rats and may be suitable for clinical therapy of second-degree burns

Keywords: Zicao ointment, Second-degree burns, Healing, Rat epidermis, Silver sulfadiazine