Li-li Zhang1,
Li-li Wang1,
Mei You2,
Zi-xuan Wei2,
Yuan Ding2,
Nan-nan Han2,
Yuan-yuan Kong1,
Xiao-yan Wang1,
Xiao-li Jin1,
Li Li1,
An-nuo Liu2 
For correspondence:- An-nuo Liu Email: luha533@163.com
Accepted: 6 July 2024 Published: 31 July 2024
Citation: Zhang L, Wang L, You M, Wei Z, Ding Y, Han N, et al. Effect of amoxicillin-clavulanate potassium and potential factors influencing umbilical cord separation time in preterm infants. Trop J Pharm Res 2024; 23(7):1189-1198 doi: 10.4314/tjpr.v23i7.18
© 2024 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the effect of amoxicillin-clavulanate potassium and potential factors influencing umbilical cord separation time in preterm infants.
Methods: A total of 151 preterm infants admitted to the Neonatology Department, First Affiliated Hospital of Anhui Medical University, Hefei, China, from November 2020 to June 2021 were selected. Preterm infants were randomly divided into control and study groups. Control group received 2 % povidone-iodine and 75 % ethanol application, followed by gentle pressure with a cotton swab while the study group received amoxicillin-clavulanate potassium applied to the umbilical cord while shaking. The management interventions were stopped after umbilical cord separation in preterm infants, and the difference in umbilical cord separation time between the two groups was compared. Factors associated with preterm birth conditions, hospitalization, and maternal health were identified by univariate and multivariate logistic regression analyses.
Results: The number of cases with umbilical cord separation time > 14 days was significantly higher in the study group compared to control group (p < 0.05). The average umbilical cord separation time in the study group was significantly lower compared to control group (p < 0.05). Univariate analysis revealed that incubator residence time significantly affects umbilical cord separation time in preterm infants (p < 0.05). Logistic multivariate regression analysis identified incubator residence time as the main factor influencing umbilical cord separation time in preterm infants.
Conclusion: The use of amoxicillin-clavulanate potassium shortens umbilical cord separation time, and incubator residence time is the major factor influencing umbilical cord separation in preterm infants. Further studies should expand the study scale and increase the number of samples used.
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