Lin Xiuqing 
,
Huang Zhiming,
Wu Fang,
Huang Erjiong,
Chen Xin,
Jin Ruifang,
Chen Renping,
Wu Wei
For correspondence:- Lin Xiuqing Email: fe1247@163.com
Accepted: 27 September 2018 Published: 31 October 2018
Citation: Xiuqing L, Zhiming H, Fang W, Erjiong H, Xin C, Ruifang J, et al. Effect of bifidobacteria on intestinal injury and flora in a mouse model of ulcerative colitis. Trop J Pharm Res 2018; 17(10):2019-2023 doi: 10.4314/tjpr.v17i10.18
© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the effect of bifidobacteria on intestinal injury and flora in a mouse model of ulcerative colitis (UC).
Methods: Mouse model of UC was produced using dextran sulphate sodium (DSS). The mice were divided into seven groups, viz, reference group, MRS-L medium-negative control group, mesalamine-positive control group, high dose bifidobacteria (MIMBb75) group, middle dose MIMBb75 group and low dose MIMBb75 group. Normal mice were used as control. All mice were sacrificed at day 7 of treatment, and colon length, hemoglobin concentration and intestinal flora were determined.
Results: Bifidobacteria inhibited UC-induced decreases in mice hemoglobin and UC-induced colon shortening. In addition, it augmented the diversity of intestinal flora and increased the number of bacteroides and Clostridium leptum.
Conclusion: Bifidobacteria plays a therapeutic role in UC via regulation of intestinal microflora.
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