Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of cinnamaldehyde on nesfatin-1 levels in diabetic rats

Nazl?can Igci¹, Nurten Akkececi¹ , Mehmet Bo?nak¹, Atila Yoldas², Nadire Eser³

¹Department of Physiology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Türkiye; ²Department of Anatomy, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Türkiye; ³Department of Pharmacology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Türkiye.

For correspondence:- Nurten Akkececi Email: seringec@hotmail.com

Accepted: 2 February 2024 Published: 29 February 2024

Citation: Igci N, Akkececi N, Bo?nak M, Yoldas A, Eser N. Effect of cinnamaldehyde on nesfatin-1 levels in diabetic rats. Trop J Pharm Res 2024; 23(2):299-305 doi: 10.4314/tjpr.v23i2.9

© 2024 The authors.
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Abstract

Purpose: To evaluate the effect of cinnamaldehyde (CA) on fasting blood glucose (FBG), body weight, lipid profile, and nesfatin-1 levels in healthy and diabetic (DM) rats.

Methods: Ten groups with eight rats per group were used. Healthy and diabetic sham groups were administered 1 mL of saline for 28 days by intragastric gavage. Healthy and diabetic control groups were administered 1 mL 0.5 % dimethyl sulfoxide (DMSO) for 28 days by intragastric gavage. Other diabetic and healthy groups (HG) received 10, 20, and 40 mg/kg CA for 28 days by intragastric gavage, once daily. Diabetes was induced with streptozotocin (50 mg/kg intraperitoneally). Rats were defined as diabetic when FBG was > 250 mg/dL. Enzyme-linked immunosorbent assay (ELISA) was used to assess serum nesfatin-1 concentrations. Fasting blood glucose (FBG) values were evaluated with a glucometer.

Results: Day 28 weights of all DM and HG + 40 mg/kg CA groups were lower than day 1 weights (p < 0.05). Triglyceride values of DM + 40 mg/kg CA group were lower than DM sham and control group (p ≤ 0.001). Low-density lipoprotein (LDL) and cholesterol levels of the CA-administered healthy groups were higher than healthy control groups (p ≤ 0.001). Nesfatin-1 levels of all DM groups were lower than all healthy groups, and nesfatin-1 levels of all CA-administered healthy and DM groups were lower than healthy and DM sham and control groups, but these were not significant (p > 0.001).

Conclusion: Although not significant, the decrease in nesfatin-1 level is evidence that CA has an anti-obesity effect in both healthy and diabetic rats. In contrast to its antihyperlipidemic effect in diabetic conditions, CA has hyperlipidemic effect in healthy conditions.

Keywords: Anti-obesity, Cinnamaldehyde, Cinnamon, Diabetes, Lipid profile, Nesfatin-1