Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of fruit/vegetable-drug interactions on CYP450, OATP and p-Glycoprotein: A systematic review

Tauqeer Hussain Mallhi¹ , Azmi Sarriff¹, Azreen Syazril Adnan², Yusra Habib Khan¹, Muhammad Imran Qadir⁴, Azhar Amir Hamzah³, Amer Hayat Khan¹

¹Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, University Sains Malaysia, Penang 11800; ²Chronic Kidney Disease Resource Centre, School of Medical Sciences, Health Campus, University Sains Malaysia; ³Urology Unit, Department of Surgery, Hospital University Sains Malaysia, Kelantan 16150, Malaysia; ⁴Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan, Pakistan.

For correspondence:- Tauqeer Mallhi Email: tauqeer.hussain.mallhi@hotmail.com Tel:+60105644191

Received: 2 August 2014 Accepted: 23 July 2015 Published: 31 October 2015

Citation: Mallhi TH, Sarriff A, Adnan AS, Khan YH, Qadir MI, Hamzah AA, et al. Effect of fruit/vegetable-drug interactions on CYP450, OATP and p-Glycoprotein: A systematic review. Trop J Pharm Res 2015; 14(10):1927-1935 doi: 10.4314/tjpr.v14i10.27

© 2015 The authors.
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Abstract

Purpose: To review the concomitant use of certain drugs with fruit/vegetable juices that may lead to drug-juice interactions resulting in medication-related problems.

Method: In this systematic review, online databases (PubMed, Google Scholar and Science Direct) were searched for information on juices derived from fruits and vegetables that are reported to have inhibitory effects on cytochrome P450, p-glycoprotein and organic anion transporting polypeptides (OATPs).

Results: Fruits can inhibit CYP1A1, CYP1A2, CYP1A4, CYP3A1, CYP3A4, CYP2C6, CYP2C9, CYP2E1 and drug transporters (P-glycoprotein, OATP). On the other hand CYP1A1, CYP1A2, CYP2A2, CYP3A1, CYP1B1, CYP2B1, CYP2B2, CYP2C1, CYP2C6, CYP2E1 can be inhibited by some vegetables. Antihypertensives, antidiabetics, statins, analgesics and antipsychotics were the most common drugs interacting with fruits and vegetables. The inhibition of their metabolism by fruits and vegetables can cause serious toxic effects, e.g., hypertension, poor glycemic control, rhabdomyolosis and drug overdose-related toxic effects. Overall, active components of fruits and vegetables can interact with many drugs leading to adverse effects.

Conclusion: Screening of fruits/vegetables for possible risk of interaction, and patient counseling are some effective strategies for preventing such interactions for optimal patient care.

Keywords: Fruits and vegetables, Cytochrome P450, Drug interactions, p-Glycoprotein, Organic anion transporting polypeptides