Jae-Eun Lee,
Min-Suk Kim,
So-Young Park 
For correspondence:- So-Young Park Email: soypark23@dankook.ac.kr Tel:+82415501434
Accepted: 16 October 2017 Published: 30 November 2017
Citation: Lee J, Kim M, Park S. Effect of natural antioxidants on the aggregation and disaggregation of beta-amyloid. Trop J Pharm Res 2017; 16(11):2629-2635 doi: 10.4314/tjpr.v16i11.9
© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To examine the relationship between higher antioxidant activity and aggregation or disaggregation of beta-amyloid (Aβ) for 21 plants.
Methods: Twenty-nine natural plant extracts and their antioxidant activities were analyzed using DPPH assay. The aggregation and disaggregation of Aβ were analyzed using Thioflavin-T assay.
Results: Eleven plant extracts exhibited high antioxidant activities with the half-maximal inhibitory concentration (IC50) values < 20.0 μg/mL. Furthermore, the plant extracts efficiently inhibited Aβ aggregation with a mean IC50 value of 17.0 μg/mL. However, four plant extracts exhibiting low antioxidant activities (IC50 > 80.0 μg/mL) inhibited Aβ aggregation less efficiently with a mean IC50 value of 75.7 μg/mL. Furthermore, plant extracts with high antioxidant activities were not invariably efficient for disaggregating pre-formed Aβ aggregates.
Conclusion: High antioxidant activities were positively correlated with the inhibition of Aβ aggregation, although not with the disaggregation of pre-formed Aβ aggregates. Nevertheless, potent antioxidants may be helpful in treating Alzheimer’s disease.
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