Romanus E Okosun1,
Matthew E Adu2
1Department of Chemical Pathology, University of Benin Teaching Hospital, Benin City, Nigeria;
2Department of Medical Laboratory Services, Antiretroviral Therapy Centre, Central Hospital, Agbor, Nigeria.
For correspondence:- Matthew Adu
Email: adumatthew10@yahoo.com
Received: 5 May 2014
Accepted: 26 April 2015
Published: 29 June 2015
Citation:
Okosun RE, Adu ME.
Effect of oral vitamin E on serum lipid profile of apparently healthy Nigerians in Benin City. Trop J Pharm Res 2015; 14(6):1071-1074
doi:
10.4314/tjpr.v14i6.19
© 2015 The authors.
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Abstract
Purpose: To investigate the effect of oral vitamin E on serum lipid profile of Apparently Healthy Nigerians in Benin City
Methods: Fifty eight apparently healthy non-smoking males aged 30 - 59 years were randomly selected from Benin metropolis and were divided in three groups. The effect of oral vitamin E (a potent antioxidant) supplementation in various dosages 100 mg/day,200 mg/day and 400 mg/day for 21 days on Total cholesterol, Triglycerides, High Density Lipoprotein, Low Density Lipoprotein and Very low Density Lipoprotein was examined.
Results: The serum total cholesterol, triglycerides, low density lipoprotein and very low density lipoprotein of the subjects showed a decrease which was not statistically significant (p > 0.05) after treatment with various doses of oral vitamin E.
Conclusion: The effect of oral vitamin E on blood lipids is not significant when administered alone to healthy male subjects. This may be due to the function of α- tocopherol (vitamin E) as a pro-oxidant in the formation of lipid radical via α- tocopherol mediated pathway.
Keywords: Atherosclerosis, Pro-oxidant, Vitamin E, Antioxidants, Lipid profile, Dyslipidaemia