Romanus E Okosun1,
Matthew E Adu2 
For correspondence:- Matthew Adu Email: adumatthew10@yahoo.com
Received: 5 May 2014 Accepted: 26 April 2015 Published: 29 June 2015
Citation: Okosun RE, Adu ME. Effect of oral vitamin E on serum lipid profile of apparently healthy Nigerians in Benin City. Trop J Pharm Res 2015; 14(6):1071-1074 doi: 10.4314/tjpr.v14i6.19
© 2015 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To investigate the effect of oral vitamin E on serum lipid profile of Apparently Healthy Nigerians in Benin City
Methods: Fifty eight apparently healthy non-smoking males aged 30 - 59 years were randomly selected from Benin metropolis and were divided in three groups. The effect of oral vitamin E (a potent antioxidant) supplementation in various dosages 100 mg/day,200 mg/day and 400 mg/day for 21 days on Total cholesterol, Triglycerides, High Density Lipoprotein, Low Density Lipoprotein and Very low Density Lipoprotein was examined.
Results: The serum total cholesterol, triglycerides, low density lipoprotein and very low density lipoprotein of the subjects showed a decrease which was not statistically significant (p > 0.05) after treatment with various doses of oral vitamin E.
Conclusion: The effect of oral vitamin E on blood lipids is not significant when administered alone to healthy male subjects. This may be due to the function of α- tocopherol (vitamin E) as a pro-oxidant in the formation of lipid radical via α- tocopherol mediated pathway.
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