Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of rPMS on N-type calcium channel in rats with neuropathic pain

Xianbin Cai, Xuefen Xu

¹Department of Pain, Ganzhou City People's Hospital, Ganzhou 341000, China; ²Department of Neurosurgery, Ganzhou City People's Hospital, Ganzhou 341000, China.

For correspondence:- Xuefen Xu Email: ab12cd7e@163.com Tel:+8618007072982

Accepted: 19 June 2022 Published: 31 July 2022

Citation: Cai X, Xu X. Effect of rPMS on N-type calcium channel in rats with neuropathic pain. Trop J Pharm Res 2022; 21(7):1479-1485 doi: 10.4314/tjpr.v21i7.18

© 2022 The authors.
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Abstract

Purpose: To investigate the effect of repetitive peripheral magnetic stimulation (rPMS) on N-type calcium channel of rats with neuropathic pain (NP).

Methods: Thirty-two Sprague-Dawley (SD) rats were randomized into control, mock surgical, model, and rPMS groups. For the model and rPMS groups, rat NP models were made based on chronic constriction injury (CCI) model from January 2018 to June 2019; the mock surgical group was treated to expose the sciatic nerve, while the control group received no treatment.

Results: Compared to the control group, the model group demonstrated a prominent increase in spontaneous pain-like behaviors, threshold of claw withdrawal in reaction to mechanical stimulation, substance P, glutamic acid, calcitonin gene-related peptide (CGRP), and calcium current, with a decrease in paw withdrawal thermal latency (PwTL) (p < 0.05). In comparison to the model group, alleviated spontaneous pain-like behaviors, reduced threshold of claw withdrawal in reaction to mechanical stimulation, substance P, glutamic acid, CGRP, and calcium current rPMS, with increased PwTL were observed in the rPMS group (p < 0.05).

Conclusion: rPMS alleviates NP syndromes and inhibits the activity of N-type calcium channel in rats. This finding provides a theoretical basis and reference for the clinical application of rPMS in the treatment of NP.

Keywords: Repetitive peripheral magnetic stimulation (rPMS), Neuropathic pain, N-type calcium channel, Paw withdrawal thermal latency