Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of ropivacaine concentrations in combined spinal-epidural anesthesia on efficacy and sedation levels in lower abdominal obesity patients

Yangling Zhu¹, Xiaoshu Zheng²

¹Department of Anesthesiology, Traditional Chinese Medicine Hospital, Lin 'an District, Hangzhou City, Zhejiang Province, China; ²Department of Surgery, No. 4 People's Hospital, Lin 'an District, Hangzhou City, Zhejiang Province, China.

For correspondence:- Xiaoshu Zheng Email: zyl3617@163.com

Accepted: 29 June 2024 Published: 31 July 2024

Citation: Zhu Y, Zheng X. Effect of ropivacaine concentrations in combined spinal-epidural anesthesia on efficacy and sedation levels in lower abdominal obesity patients. Trop J Pharm Res 2024; 23(7):1207-1213 doi: 10.4314/tjpr.v23i7.20

© 2024 The authors.
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Abstract

Purpose: To investigate the effect of varying ropivacaine concentrations in combined spinal-epidural anesthesia (CSEA) on anesthetic efficacy and sedation in patients with lower abdominal obesity.

Methods: 110 patients with lower abdominal obesity who received CSEA in Traditional Chinese Medicine Hospital, Lin 'an District, Hangzhou, China from January 2020 to December 2022 were retrospectively enrolled. Patients were divided into a low-concentration group (LC group, n = 49) which received 0.3 % ropivacaine, and a high-concentration group (HC group, n = 61) which received 0.5 % ropivacaine. Changes in visual analogue scale (VAS) scores and Ramsay sedation scale (RSS) scores in both groups were analyzed at 1, 2, 4 and 6 h after surgery.

Results: The LC group showed significantly higher static and dynamic VAS scores than HC group at 1, 2, 4 and 6 h after surgery. Furthermore, HC group demonstrated significantly shorter (p < 0.05) onset times for sensory and motor blocks, longer sensory and motor recovery times, and lower mean arterial pressure (MAP) level 10 min after administration compared to the LC group. However, MAP levels 30 min after administration were similar to baseline levels in both groups (p > 0.05).

Conclusion: High-concentration ropivacaine in CSEA offers superior post-operative analgesia, and improves patient satisfaction without increasing adverse reactions in patients with lower abdominal obesity. Further studies using larger sample size and longer duration of investigation are required to strengthen the validity of these results.

Keywords: Spinal-epidural anesthesia, Anesthetic effect, Sedation score, lower abdominal obesity