Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of scopoletin on fascia-wrapped diced cartilage grafts

Ning Zeng, Yi Xu, Xian Wang, Yiping Wu, Haiping Wang

Plastic and Aesthetic Surgery, Tongji Hospital, Fongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province 430030, China;

For correspondence:- Haiping Wang Email: wanghaiping7@hotmail.com Tel:+86273692814

Received: 13 January 2017 Accepted: 20 June 2017 Published: 31 July 2017

Citation: Zeng N, Xu Y, Wang X, Wu Y, Wang H. Effect of scopoletin on fascia-wrapped diced cartilage grafts. Trop J Pharm Res 2017; 16(7):1609-1613 doi: 10.4314/tjpr.v16i7.20

© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To evaluate the effect of scopoletin (SL) on fascia-wrapped diced cartilage grafts in rhinoplasty surgery.

Methods: Cartilage grafts (2 × 2 cm) from the ears of New Zealand rabbits were diced into sections (1 mm³) and then wrapped in muscle fascia taken from the right rear leg. Each graft was placed on the back of the animal after measuring its weight, and then the rabbits were separated into two groups, viz, control and the SL-treated groups {10 mg/kg, per os (p.o.)}. The treatments were administered for 3 months, the rabbits were sacrificed, and the histopathological features and weight of the grafts were examined.

Results: The weight of the grafts in the two groups did not significantly (p < 0.05) differ but the histopathological results suggested that there was a pronounced increase in the viability of the graft tissues in the SL-treated group compared to the control group. Treatment with SL decreased the resorption rate and enhanced basophilia relative to the control group. However, fibrosis, inflammation, and bone metaplasia- and calcification-like factors did not significantly differ (p < 0.05).

Conclusion: Treatment with SL significantly enhances the viability of the grafts, and thus may have a beneficial effect on fascia-wrapped diced cartilage grafts.

Keywords: Scopoletin, Rhinoplasty surgery, Fascia-wrapped diced cartilage graft, Histopathology, Basophilia, Inflammation