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Original Research Article | OPEN ACCESS

Effect of sodium aescinate on methyl parathion-induced myocardial injury in rats

Junjie Wen1, Zhan Su2 , Suxin Luo3, Tian Tuo1

1Department of Cardiology; 2Department of Gynecology, The People's Hospital of Guang'an City, Guang’an 638000; 3Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

For correspondence:-  Zhan Su   Email: Suzhanjkij@163.com   Tel:+868262600300

Accepted: 29 November 2018        Published: 26 December 2018

Citation: Wen J, Su Z, Luo S, Tuo T. Effect of sodium aescinate on methyl parathion-induced myocardial injury in rats. Trop J Pharm Res 2018; 17(12):2415-2320 doi: 10.4314/tjpr.v17i12.15

© 2018 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To explore the effects and mechanism of sodium aescinate (SA) on methyl parathion (MP)-induced myocardial injury.
Methods: Rats were divided into following groups: In Control group, rats were administered 0.9 % NaCl by intraperitoneal injection. In MP group, rats were administered 20 mg/kg MP by intraperitoneal injection. In MP + SA group, rats were administered 20 mg/kg MP in combination with SA at a concentration of 0.5, 1.0, or 1.5 mg/kg by intraperitoneal injection. Histological changes were assessed by H&E staining. Serum levels of cardiac troponin T (CTnT) and atrial natriuretie peptide (ANP) were measured by automatic biochemical analyzer and real-time polymerase chain reaction (RT-PCR), respectively. The levels of malondiadehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH - Px), and glutathione (GSH) in heart tissue was detected by spectrophotometry. The apoptosis of myocardial cells was measured by the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay. The level of apoptosis-related proteins was assessed by western blot.
Results: Superoxide dismutase attenuated MP-induced myocardial injury, and decreased the levels of ANP and cTnT in serum (p < 0.01). Superoxide dismutase attenuated the MP-induced decrease in GSH, GSH-px, and SOD expression (p < 0.05) but increased MDA level (p < 0.01). Moreover, SA inhibited the apoptosis of myocardial cells and regulation of apoptosis-related protein expression (e.g., Bax, Bcl-2, and caspase 3).
Conclusion: These results demonstrate that SA attenuates MP-induced myocardial injury by regulating oxidative stress and apoptosis.

Keywords: Sodium Aescinate, Methyl Parathion, Acute Organophosphorus Pesticide Poisoning, Myocardial Injury

Impact Factor
Thompson Reuters (ISI): 0.6 (2023)
H-5 index (Google Scholar): 49 (2023)

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