Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of the combination of Huoxue Busui decoction and hollow screw internal fixation on treatment of femoral neck fractures

Fengtao Zhou¹, Dianyun Wang², Lifang Han³, Liang Li³, Bo Ning⁴ ,

¹Department of Pharmacy, Dongying People's Hospital, Dongying Hospital Affiliated to Shandong Provincial Hospital Group, Dongying 257091, China; ²Department of Traditional Chinese Medicine, Dongying People's Hospital, Dongying Hospital Affiliated to Shandong Provincial Hospital Group, Dongying 257091, China; ³Department of Traditional Chinese Medicine, Dongying Hospital Affiliated to Shandong Provincial Hospital Group, Dongying 257091, China; ⁴Department of Joint Surgery, Dongying People's Hospital, Dongying Hospital Affiliated to Shandong Provincial Hospital Group, Dongying 257091, China.

For correspondence:- Bo Ning Email: Ningbo_dyrmyy@163.com

Accepted: 29 June 2024 Published: 31 July 2024

Citation: Zhou F, Wang D, Han L, Li L, Ning B, Effect of the combination of Huoxue Busui decoction and hollow screw internal fixation on treatment of femoral neck fractures. Trop J Pharm Res 2024; 23(7):1199-1205 doi: 10.4314/tjpr.v23i7.19

© 2024 The authors.
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Abstract

Purpose: To determine the effect of Huoxue Busui decoction plus hollow screw internal fixation in adolescent and middle-aged patients with fractures of the femoral neck.

Methods: 56 patients receiving treatment for fracture with hollow screw internal fixation in the emergency rapid diagnosis and treatment channel of Dongying People's Hospital, China from April 2015 to January 2023 were randomly assigned to study and control groups. The two groups received hollow screw internal fixation and conventional drug therapy, but in addition, control group were given Huoxue Busui decoction 2 days after surgery. Visual analogue scale (VAS), hip efficacy score and hip flexor-extension range of motion pre- and post-operation were analyzed.

Results: Preoperative VAS score and postoperative garden alignment index (GAI) of fracture reduction were comparable in the two groups. The VAS scores of control group at 5 days, 7 days, 1 month and 12 months after surgery were significantly lower than study group (p < 0.05). Fracture healing time was shorter in study group. At the last follow-up, there was no case of fracture non-union in control group. However, there were 2 cases of nail withdrawal and 1 case of femoral head necrosis. In contrast, study group had 1 instance of non-union, 3 instances of nail removal and 4 instances of femoral head necrosis.

Conclusion: Huoxue Busui decoction combined with hollow screw internal fixation improved femoral neck fracture in young and middle-aged patients and promotes fracture healing after surgery and effectively improves joint function of patients. However, longer follow-up time, and in-depth study of the mechanism of action of this combination will be required.

Keywords: Huoxue Busui decoction, Hollow screw internal fixation, Femoral neck fracture, Emergency rapid diagnosis