Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of the combination of dexmedetomidine and sufentanil after laparoscopic cholecystectomy in patients with gallbladder diseases

Yan Chen¹, Xiangliu Liu², Gaohua Wang¹, Haifeng Guo³

¹Department of Anesthesiology, Jingxian Hospital, Anhui Province, China; ²Department of Anesthesiology, Jinling Hospital; Medical School of Nanjing University, Nanjing, Jiangsu Province, China; ³Department of Anesthesiology, Air Force Hospital, Eastern Theater Command of PLA, Nanjing, Jiangsu Province, China.

For correspondence:- Haifeng Guo Email: guohf1024@163.com

Accepted: 27 July 2024 Published: 31 August 2024

Citation: Chen Y, Liu X, Wang G, Guo H. Effect of the combination of dexmedetomidine and sufentanil after laparoscopic cholecystectomy in patients with gallbladder diseases. Trop J Pharm Res 2024; 23(8):1307-1313 doi: 10.4314/tjpr.v23i8.10

© 2024 The authors.
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Abstract

Purpose: To investigate the effect of dexmedetomidine plus sufentanil on in-patients after laparoscopic cholecystectomy (LC).

Methods: A total of 120 patients with gallbladder disease in Jingxian Hospital, China who were treated with LC were assigned equally to control and study cohorts. Control group received sufentanil, while study group received dexmedetomidine and sufentanil after surgery. The extent of sedation, degree of pain, and dosage of self-controlled analgesia pump drug, were evaluated within 48 h. Serum levels of stress indicators such as cortisol (Cor), norepinephrine (NE), angiotensin II (AngII), reactive oxygen species (ROS), and inflammatory factors: interleukin-17 (IL-17), tumor necrosis factor-alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP) were determined.

Results: Values of Ramsay sedation scores after surgery in study group were significantly higher than those in control group (p < 0.05). The visual analogue scale (VAS) scores were significantly lower in study group than in control group. The self-controlled analgesia pump drug dosages were significantly lower in study cohort (p < 0.05). Study cohort had lower levels of Cor, NE, AngII, TNF-α, and hs-CRP after surgery than control cohort, while SOD level was higher in study cohort than in control cohort (p < 0.05). There was a significantly lower incidence of adverse reactions in study cohort.

Conclusion: The combination of dexmedetomidine and sufentanil as postoperative analgesia in LC significantly improves sedation and analgesia, reduces sufentanil use, alleviates stress response and inflammation, and reduces adverse reactions. Future long-term and large-scale monitoring is required to further validate these findings.

Keywords: Laparoscopic cholecystectomy (LC), Dexmedetomidine, Sufentanil, Analgesia, Stress response