Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of vitamin K2 on bone mineral density and serum cathepsin K in female osteoporosis patients

Gu Yuanyang, Xing Runlin, Xu Bo, Fan Donghua, Mao Jun

Department of Orthopedics, Affiliated Hospital of Nanjing University of Chinese Medicine, Hanzhong Road 155#, Nanjing, Jiangsu Province 210029, China;

For correspondence:- Mao Jun Email: z005977@163.com

Accepted: 30 December 2018 Published: 31 January 2019

Citation: Yuanyang G, Runlin X, Bo X, Donghua F, Jun M. Effect of vitamin K2 on bone mineral density and serum cathepsin K in female osteoporosis patients. Trop J Pharm Res 2019; 18(1):181-185 doi: 10.4314/tjpr.v18i1.27

© 2019 The authors.
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Abstract

Purpose: To investigate the influence of vitamin K₂ on bone mineral density, bone metabolism and serum tissue protease K (cathepsin K) in female patients with osteoporosis.

Method: A total of 210 osteoporosis patients in Affiliated Hospital of Nanjing University of Chinese Medicine who met the inclusion criteria were selected from January 2017 to January 2018. The patients were randomly divided into vitamin K₂ group, strontium renate group and blank control group (70 patients/group). Strontium ranelate group was orally given 2 g of strontium ranelate daily, while vitamin K₂ group received 15 mg of Gulikang capsule 3 times a day. Bone mineral density (BMD) and serum osteocalcin (BGP), β-collagen degradation product (β-crosslaps), type I procollagen amino terminal pro-peptide (PINP), cathepsin K (cathe K) and TRAP were measured prior to drug treatment, and six months after surgery, using standard procedures.

Results: Relative to the blank control, hip and lumbar spine density of vitamin K₂ and strontium ranelate groups increased to varying degrees. Strontium ranelate group had significantly higher bone mineral density (BMD) than any other groups (p < 0.05), and also had the lowest osteoclast activity (β-crosslaps and TRAP) and the highest osteogenic activity (BGP and PINP). On the other hand, osteoclast and osteogenic activities increased significantly (p < 0.05) in the vitamin K₂ group.

Conclusion: Appropriate vitamin K₂ treatment improves BMD in the hip and waist of women with osteoporosis by promoting osteogenic activity, and by reducing osteoclast activity and cathepsin K expression.

Keywords: Osteoporosis, Bone mineral density, Strontium ranelate, Vitamin K2