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Original Research Article | OPEN ACCESS

Efficacy of intraperitoneal ghrelin in the treatment of acetic acid-induced colitis

Fatma Yilmaz1 , Seyfettin Koklu2, Erdem Kocak3, Huseyin Ustun4

1Department of Hematology, Ankara Etlik City Hospital; 2Department of Gastroenterology, Private 19 May?s Hospital; 3Department of Gastroenterology, Istinye University Faculty of Medicine; 4Department of Pathology, Synlab Laboratories, Ankara, Turkey.

For correspondence:-  Fatma Yilmaz   Email: dr.fatmak@hotmail.com   Tel:+90-5068823869

Received: 14 July 2024        Accepted: 6 October 2024        Published: 30 October 2024

Citation: Yilmaz F, Koklu S, Kocak E, Ustun H. Efficacy of intraperitoneal ghrelin in the treatment of acetic acid-induced colitis. Trop J Pharm Res 2024; 23(10):1741-1747 doi: 10.4314/tjpr.v23i10.20

© 2024 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the effectiveness of intraperitoneal administration of ghrelin in the treatment of acetic acid-induced colitis. Method: A total of 30 Wistar-Albino rats were randomly and equally assigned to control, colitis-induced and study groups. The control group received normal saline (2 mL, 0.9 % w/v rectally). Colitis was induced with acetic acid (2 mL rectally). The study group administered ghrelin (3 - 7 nmol) intraperitoneally for 5 days after induction with acetic acid. Ghrelin was administered 1 h after acetic acid induction. Results: Macroscopic damage scores were significantly higher in colitis-induced group compared to control group (p < 0.001). However, macroscopic scores were significantly lower in study group (treated with ghrelin) compared to other groups (p < 0.001). Furthermore, MDA levels were significantly higher in colitis-induced group and study groups (p < 0.01) compared to control group. There was no significant difference in total antioxidant capacity (TAC) in all groups. Conclusion: Ghrelin significantly lowers macroscopic damage and MDA levels in acetic-acid colitis. Further long-term studies on intraperitoneal ghrelin treatment in chronic colitis models may be able to clearly show the effects of treatment on oxidative markers.

Keywords: Colitis, Ghrelin, Malondialdehyde, Total antioxidant capacity

Impact Factor
Thompson Reuters (ISI): 0.523 (2021)
H-5 index (Google Scholar): 39 (2021)

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