Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Evaluation of Moringa oleifera Leaf Extract on Alcohol-induced Hepatotoxicity

M S Nadro, R m Arungbemi,, D . Dahiru

Department of Biochemistry Federal University of Technology, Yola P.M.B. 2076, Yola, Adamawa State;

For correspondence:- D Dahiru Email: ddahiru2000@yahoo.com

Published: 27 June 2006

Citation: Nadro MS, Arungbemi, Rm, Dahiru D.. Evaluation of Moringa oleifera Leaf Extract on Alcohol-induced Hepatotoxicity. Trop J Pharm Res 2006; 5(1):539-544 doi: 10.4314/tjpr.v5i1.3

© 2006 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

A study on the protective effect of Moringa oleifera leaf extract in acute alcohol-induced hepatotoxicity in rats was evaluated. Rats fed alcohol only produced significant increase in the levels of enzyme markers of tissues damage (ALT, AST and ALP), lipid peroxidation (TBARS) and decreased serum vitamin C levels compared to normal control rats.
Pretreatment with 100 and 200mg/kg body weight of extract significantly decreased the levels of enzyme markers, lipid peroxidation and markedly increased serum vitamin C level in a dose-dependent manner. Post-treatment with 200mg/kg body weight of extract significantly enhanced the recovery of animals from hepatic damage compared to untreated control. Lipid peroxidation and depletion of vitamin C due to oxidative stress could be the possible mechanisms of alcohol induced toxicity and the protective effect of the extract could be as a result of its ability to inhibit lipid peroxidation and prevent the depletion of vitamins C.

Keywords: Moringa oleifera, hepatotoxicity, lipid peroxidation, vitamin C