Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Evaluation of prophylactic Effect of Remifentanil on Succinylcholine-Induced Myalgia in Humans

Karim Nasseri¹ , Mehdi Taibi Arasteh², Abdorrahim Afkhamzadeh³, Saeed Hakhamaneshi⁴

¹Department of Anesthesia and Intensive Care, Kurdistan Research Center for Social Determinants of Health, (KRCSDH), School of Medicine; ²Department of Anesthesia and Intensive Care; ³Department of Community Medicine, Kurdistan Research Center for Social Determinants of Health, (KRCSDH); ⁴Department of Microbiology, Kurdistan University of Medical Sciences, Sanandaj, Iran.

For correspondence:- Karim Nasseri Email: nasseri_k@muk.ac.ir Tel:+88716660733

Received: 28 January 2013 Accepted: 18 October 2014 Published: 15 December 2014

Citation: Nasseri K, Arasteh MT, Afkhamzadeh A, Hakhamaneshi S. Evaluation of prophylactic Effect of Remifentanil on Succinylcholine-Induced Myalgia in Humans. Trop J Pharm Res 2014; 13(12):2027-2030 doi: 10.4314/tjpr.v13i12.12

© 2014 The authors.
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Abstract

Purpose: To assess the efficacy of remifentanil in preventing succinylcholine-induced myalgia in humans.

Methods: Sixty healthy adults scheduled for elective surgery under general anesthesia were enrolled in a double-blind study and randomly allocated to two groups of thirty patients. Patients in Group I (remifentanil group) were pretreated with remifentanil 1 μg/kg one minute prior to induction of anesthesia, while patients in Group II (saline group) received an equivalent volume of saline. Anesthesia was induced in both groups with fentanyl 1 μg/kg, propofol 2.0 mg/kg and succinylcholine 1.5 mg/kg. Postoperative myalgia was assessed 12, 24, and 48 h after induction and graded as nil, mild, moderate, or severe.

Results: Fifty nine patients completed the study. The demographic data for both groups were comparable (p > 0.05). Postoperative myalgia at 12, 24, and 48 h after induction were 34.5, 34.5 and 14.1 % in group I, and 60, 53.4 and 30 % in group II, respectively (p > 0.05).

Conclusion: Prophylactic use of remifentanil 1 μg/kg intravenously is ineffective in the prevention of postoperative myalgia.

Keywords: Remifentanil, Succinylcholine, Myalgia, Propofol, Prophylaxis