Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

External application of Ruyi Jinhuang powder for phlebitis: A systematic review and meta-analysis

Qian Yang¹, Chunyan Yang², Yongqiong Deng³, Qunhua Ma⁴

¹Nursing School, Southwest Medical University, No. 3, 319 Section of ZhongShan Road, Jiangyang District; ²Department of Dermatology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, No. 16, Chunhui Road, Longma Tan District; ³Department of Dermatology, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Jiangyang District, Luzhou 646000; ⁴Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital MICU, Chengdu, Sichuan 610072, China.

For correspondence:- Qunhua Ma Email: qunhua_ma@163.com Tel:+862887393999

Accepted: 17 February 2019 Published: 31 March 2019

Citation: Yang Q, Yang C, Deng Y, Ma Q. External application of Ruyi Jinhuang powder for phlebitis: A systematic review and meta-analysis. Trop J Pharm Res 2019; 18(3):647-667 doi: 10.4314/tjpr.v18i3.29

© 2019 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To systematically review the effectiveness of the external application, Ruyi Jinhuang powder, on phlebitis

Methods: Relevant literature was retrieved from Medline, Embase, China National Knowledge Infrastructure database (CNKI), Cochrane Central Register, Chongqing Vip, Wanfang Data and SinoMed using the search terms “Ruyi Jinhuang San”, “Ruyi Jinhuang powder”, “Ruyi Jinhuang cream”, “Agreeable golden powder”, “satisfactory golden powder”, “Jinhuang cream”, “phlebitis”, “prevention and (or) treatment”, “randomized controlled trials” and “RCRs”. Two researchers independently arranged and analyzed the data.

Results: Significant differences were observed in the total effectiveness rate of Ruyi Jinhuang powder [relative risk (RR) = 1.27, 95% confidence interval (CI) = 1.19 to 1.36, and p < 0.0001). Ruyi Jinhuang powder can reduce the incidence of phlebitis versus conventional therapy in preventing phlebitis (RR = 0.32, 95 % CI 0.24 to 0.42, and p < 0.0001). Shorten the average healing time [mean difference (MD) =-32.17, 95 % CI= -48.39 to -15.94, and p = 0.0001). Reduced pain relief time for phlebitis (MD = -3.29, 95% CI -5.42 to -1.16, and p = 0.002). However, no statistical difference was observed with regard to the onset time of phlebitis (MD = -0.62, 95 % CI -1.76 to 0.52, and p = 0.29).

Conclusion: Clinicians consider Ruyi Jinhuang powder a viable complementary and alternative medicine for phlebitis following the stronger evidence being offered.

Keywords: Ruyi Jinhuang powder; Prevention and treatment; Phlebitis; Meta-analysis