Ganesh Chaulang 
,
Piyush Patel,
Sharwaree Hardikar,
Mukul Kelkar,
Ashok Bhosale,
Sagar Bhise
For correspondence:- Ganesh Chaulang Email: ganesh_chaulang@rediffmail.com Tel:+919923968989
Received: 30 August 2008 Accepted: 20 October 2008 Published: 23 February 2009
Citation: Chaulang G, Patel P, Hardikar S, Kelkar M, Bhosale A, Bhise S. Formulation and Evaluation of Solid Dispersions of Furosemide in Sodium Starch Glycolate. Trop J Pharm Res 2009; 8(1):43-51 doi: 10.4314/tjpr.v8i1.7
© 2009 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: This investigation was carried out to determine if a solid dispersion of furosemide in sodium starch glycolate (SSG) would enhance the dissolution properties of the drug.
Methods: Solid dispersion of furosemide in SSG was prepared in ratios of 1:1 and 1 (furosemide):2 (SSG) by kneading method. In each case, the solid dispersion was characterized by Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), and X-ray diffraction (XRD) to ascertain if there were any physicochemical interactions between drug and carrier that could affect dissolution. Tablets containing the solid dispersion were formulated and their dissolution characteristics compared with commercial furosemide tablets. The dissolution studies were performed at 37 ± 0.5oC and 50 rpm in simulated gastric fluid (pH 1.2).
Results: FTIR spectroscopy, DSC, and XRD showed a change in crystal structure toward an amorphous form of furosemide. Dissolution data indicated that furosemide dissolution was enhanced. XRD, DSC, FTIR spectroscopy and dissolution studies indicated that the solid dispersion formulated in 1:2 ratio showed a 5.40-fold increase in dissolution and also exhibited superior dissolution characteristics to commercial furosemide tablets.
Conclusion: Solid dispersion technique can be used to improve the dissolution of furosemide.
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