Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Formulation and Evaluation of Spray-Dried Esomeprazole Magnesium Microspheres

Achin Jain, Ravi MN Teja, Laxman Pariyani, B Balamuralidhara, Vishal N Gupta

Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagar, Mysore - 570 015, Karnataka, India;

For correspondence:- Vishal Gupta Email: vkguptajss@gmail.com Tel:+918212548353

Received: 4 September 2012 Accepted: 19 April 2013 Published: 12 June 2013

Citation: Jain A, Teja RM, Pariyani L, Balamuralidhara B, Gupta VN. Formulation and Evaluation of Spray-Dried Esomeprazole Magnesium Microspheres. Trop J Pharm Res 2013; 12(3):299-304 doi: 10.4314/tjpr.v12i3.4

© 2013 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To prepare and evaluate in vitro mucoadhesive esomeprazole magnesium microspheres for the treatment of Zollinger Ellison syndrome.

Methods: The microspheres were prepared by spray drying technique using locust bean and xanthan gums as polymers. Esomeprazole magnesium was entrapped in the microspheres at various polymer/cross-linking ratios. Glutaraldehyde was used to cross-link the gums. The microspheres were evaluated for their micromeritic properties and in vitro release. as well as by Fourier transform infrared (FTIR), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM).

Results: The microspheres were discrete, spherical, and showed good drug entrapment efficiency (60.5 - 92.3 %). FTIR and DSC results indicate that the drug was compatible with the polymers used. Amongst all the formulations, F6 (drug:locust bean gum:xanthan gum, 1:2:2) showed the most suitable sustained release properties with 99.8 % of drug released at the end of 12 h.

Conclusion: Microspheres prepared using locust bean and xanthan gums can be used as a sustained release delivery system for esomeprazole magnesium.

Keywords: Spray drying, Microspheres, Esomeprazole magnesium, Sustained release