Md Shafayat Hossain1,2 
,
Md Abdullah Shamim1,3,
Md Saifuzzaman1,
Md Attiquzzaman1,
Md Golam Hossain1,
Obayed Raihan4,5
For correspondence:- Md Shafayat Hossain Email: shafayatbd@gmail.com
Accepted: 16 May 2020 Published: 30 June 2020
Citation: Hossain M, Shamim M, Saifuzzaman M, Attiquzzaman M, Hossain M, Raihan O. Formulation and development of a topical combination cream for arthritis management. Trop J Pharm Res 2020; 19(6):1125-1130 doi: 10.4314/tjpr.v19i6.1
© 2020 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To design and prepare a non-prescription cream for cost-effective, potent, rapid and long-lasting relief from arthritic pain.
Method: The cream was prepared by formulating the aqueous phase using glucosamine sulphate, potassium chloride and chondroitin sulphate sodium, and then pouring it into the oil phase under suitable conditions. The physicochemical and antimicrobial properties, in vitro and ex vivo drug release, and overall physical and chemical stability of the formulations were characterized.
Results: Sodium metabisulfite (0.5 %) and butylated hydroxyanisole (BHA) (0.01 %) showed a very strong synergistic effect on overall stability of the cream.
Conclusion: This study confirms that the formulated cream is potentially suitable for the management of arthritis pain in patients.
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