S O Majekodunmi1,
O A Adegoke2,
O A Odeku1 
For correspondence:- O Odeku Email: pejuodeku@yahoo.com Tel:+2348033235828
Published: 21 June 2008
Citation: Majekodunmi SO, Adegoke OA, Odeku OA. Formulation of the extract of the stem bark of Alstonia boonei as tablet dosage form.. Trop J Pharm Res 2008; 7(2):987-994 doi: 10.4314/tjpr.v7i2.9
© 2008 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To formulate the extracts of the stem bark of Alstonia boonei, an important antimalarial herb, into tablet dosage form.
Methods: Tablets were formulated using direct compression and wet granulation methods. The mechanical properties of the tablets were assessed using crushing strength and friability and the crushing strength:friability ratio (CSFR) while drug release properties were evaluated using disintegration and dissolution times.
Results: There were statistically significant (p<0.01) differences in the CSFR values and drug release properties of A. boonei tablets prepared by both methods. The differences depended on the type and concentration of excipient and binder employed in the formulation.
Conclusions: The method of preparation of the A. boonei tablets needs to be carefully selected to ensure the production of tablets with adequate bond strength to withstand the rigours of handling and at the same time release the active compound (s) for biological action.
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